Rozakan Plus Tablet

Adult dose

The standard dosage of this medication is 1 tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily. Dosages exceeding Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg daily is not preferable. 1. Initiate treatment with 1 tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily, and if blood pressure is not controlled after 3 weeks, escalate to a maximum of Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg once daily.

Child dose

There is no experience of use in pediatric patients and adolescents (under 18 years), so this medication is not administered.

This medication can severely harm the fetus when taken during pregnancy, especially in the second and third trimesters, so it should be discontinued immediately once pregnancy is confirmed. Patients with allergies to this medication, severely impaired kidney function, severe liver disease, or pregnant women should not take it. Caution should be exercised when taking this medication in older adults or individuals with diseases such as hypotension, kidney dysfunction, liver disease, electrolyte imbalance, diabetes, or gout, and regular testing is required. This medication lowers blood pressure and may cause dizziness or drowsiness, so care should be taken when driving or operating machinery. As it may affect potassium levels, potassium supplements or potassium-containing medications should not be taken without consulting a physician. It is important to regularly check kidney function and electrolyte status through blood tests while taking this medication. Due to the hydrochlorothiazide component, skin may become sensitive to sunlight, so exposure to sunlight should be avoided, and attention should be paid to ultraviolet protection. This medication can interact with other medications, so it is essential to inform healthcare professionals about any other drugs being taken, especially when combined with diuretics, antihypertensives, lithium, and non-steroidal anti-inflammatory drugs (NSAIDs). In case of overdose, hypotension or arrhythmias may occur, so immediate medical attention is required. This medication is not recommended for use in children and adolescents, as safety and efficacy have not been established. If unusual symptoms or discomfort occur during use, immediately consult a physician or pharmacist.

Serious side effects

• Hives, severe swelling (edema), angioedema (swelling of the lips and eyelids and facial rash), angioedema (swelling in the throat that can cause airway obstruction/laryngeal or glottal swelling, swelling of the face/lips/pharynx/tongue)
• Severe rashes with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis)
• Shortness of breath or difficulty breathing, respiratory distress, asthma attacks, cough + fever

Mild side effects

• Systemic: Abdominal pain, weakness, fatigue, diarrhea, nausea, headache
• Cardiovascular: Palpitations, arrhythmias (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), hypotension, myocardial infarction, secondary AV block
• Gastrointestinal: Loss of appetite, constipation, toothache, dry mouth, dyspepsia, flatulence, gastritis, vomiting
• Neurosensory: Anxiety, anxiety disorders, ataxia, confusion, depression, nightmares, sensory impairment, insomnia, decreased libido, memory impairment, paresthesia

This medication is sensitive to light, so it should be stored in a container that does not allow light to enter. Additionally, it should be stored at room temperature between 1 to 30 degrees Celsius. This will help maintain the medication's efficacy.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle