Sulprim Injection

Adult dosage

Adults and children over 12 years: Administer 10 mL as a single dose, intravenous drip every 12 hours. For severe infections, administer 15 mL as a single dose. Dosage adjustment for patients with renal impairment: Creatinine clearance > 30 ml/min: standard dosage 15-30 ml/min: 1/2 dosage < 15 ml/min: not to be administered The maximum dosage in the above should not be given continuously for more than 3 days. Pneumocystis carinii pneumonia

Children's dosage

It is preferable not to administer to infants under 2 months of age. Children under 11 years: Administer Trimethoprim 6 mg and Sulfamethoxazole 30 mg per kilogram of body weight split into two doses daily. 6

This medication may cause serious side effects such as severe skin reactions, so if initial symptoms like a rash, sore throat, or fever occur, use should be discontinued immediately. It is advisable not to use this medication for treating pharyngitis caused by Streptococcus. When using the ampoule, it should be opened carefully to avoid contamination with glass fragments, and extra caution should be taken when administering to children or the elderly. Benzyl alcohol contained in this medication may pose risks to premature infants, thus caution is required. Propylene glycol, used as a solvent, may cause kidney damage or central nervous system issues if administered in large doses, so the patient's condition must be closely monitored while using this medication. This medication should not be given to those with hypersensitivity to it, pregnant women, newborns, or premature infants. Patients with blood disorders, liver dysfunction, kidney impairment, elderly patients, those with allergic constitutions, and patients with glucose-6-phosphate dehydrogenase deficiency should use this medication with caution. Blood-related side effects, skin abnormalities, liver and kidney function abnormalities, and neuropsychiatric symptoms may occur, so if symptoms appear, administration should be stopped immediately and medical advice sought. This medication may interact with other drugs, so if other medications are being taken, it is essential to inform healthcare professionals and exercise caution. It is safest for pregnant or nursing women to avoid this medication, especially in newborns or premature infants. When administering to the elderly, dosage should be adjusted considering kidney and liver function, and side effects should be closely monitored. Regular blood tests along with liver and kidney function assessments should be performed before and during administration to detect side effects early and respond accordingly. Care should be taken to prevent the medication from leaking out of the blood vessel during administration, and if this occurs, administration should be stopped, and a different site should be used. This medication may cause thyroid dysfunction, so it is advisable to monitor thyroid status during prolonged use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blistering, skin peeling, mucosal pain in the mouth/eyes, difficulty breathing or shortness of breath, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis,

Mild side effects

• Fever
• sore throat
• joint pain
• cough
• purpura
• itching
• blisters
• rash
• photosensitivity
• elevated AST

This medication should be stored in a tightly closed container that blocks light, and the storage temperature should be maintained between 1 and 30 degrees Celsius. This ensures the medication remains stable and safe to use.

Appearance

Brown ampoule filled with a colorless and transparent liquid

Package unit

(5mL/ampoule)×10