Denticole Tablets

Adult dosage

Adults and children over 15 years: 2 tablets orally, 2-3 times a day.

Children's dosage

Ages 10-14: 1 tablet orally, 3 times a day. Ages 5-9: 1 tablet orally, 2 times a day.

This medication should not be used by individuals allergic to imidazole medications or spiramycin, those sensitive to gluten, children under 6 years of age, those taking disulfiram or alcohol, and patients currently taking mizolastine. When taking this medication, skin reactions such as rash, itching, flushing, urticaria, and pustular eruptions may occur, and in severe cases, serious immune reactions like angioedema or anaphylactic shock may also arise. Gastrointestinal side effects may include abdominal pain, nausea, vomiting, diarrhea, oral mucositis, dysgeusia, decreased appetite, and rarely, pancreatitis. In the blood system, leukopenia, agranulocytosis, and thrombocytopenia may occur, while in the nervous system, symptoms such as dizziness, coordination impairment, ataxia, neuritis, and meningitis may rarely manifest, necessitating immediate discontinuation of the medication if these symptoms occur. Neuropsychiatric symptoms may include confusion, hallucinations, and depression. Ocular side effects may include diplopia, myopia, blurred vision, decreased vision, and alteration of color vision. Hepatic functional abnormalities or cholestatic hepatitis have also been rarely reported, and sensory changes or oral dryness, headaches, and seizures may occur as neurological symptoms. To prevent the development of resistant bacteria, susceptibility tests should be conducted and the medication taken for the minimum necessary duration. Patients with severe neurological conditions should exercise caution when taking this medication, as symptoms may worsen, and alcohol consumption should be strictly avoided. Prolonged or excessive use may require blood tests to check leukocyte levels, and patients should be informed that the urine may change to a reddish-brown color while taking this medication. Additionally, confusion, drowsiness, hallucinations, seizures, and visual disturbances may arise when taking this medication, so driving or operating machinery should be avoided. This medication may interact with other drugs, particularly when taken with spiramycin, disulfiram, warfarin, vecuronium, fluorouracil, and mizolastine, thus requiring caution. It is advisable to avoid use during the first three months of pregnancy, and breastfeeding should be discontinued as this medication can be transmitted through breast milk. This medication may cause false-positive results in syphilis tests, so this should be taken into consideration during testing. For storage, keep out of reach of children and do not transfer to another container for safety.

Serious side effects

Urticaria, angioedema, anaphylactic shock, vasculitis including Henoch-Schönlein purpura, agranulocytosis, thrombocytopenia, aseptic meningitis, very rare jaundice, sudden and very severe headache symptoms, encephalopathy (confusion), leukopenia

Mild side effects

Rash, itching, flushing, pustular eruptions, upper abdominal pain, nausea, vomiting, diarrhea, oral mucositis, taste disturbances, reduced appetite, dizziness, coordination impairment, ataxia, sensory disturbances, confusion, hallucinations, depressive moods, diplopia, myopia, blurred vision, decreased vision, alteration of color vision, optic nerve disorders, optic neuritis, taste changes due to metronidazole (metallic), oral dryness, glossitis, stomatitis, headaches, seizures, subacute cerebellar syndrome

This medication should be stored in a tightly sealed container that allows for good air circulation, preferably in a cool and dry place. Storing it this way will help maintain the effectiveness of the medication for a longer period.

Appearance

White round film-coated tablets

Package unit

Company packaging unit