Brenzept Tablets 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before sleep. If abnormal dreams, nightmares, or insomnia occur, consideration can be given to morning dosing. For 4-6 weeks, a dose of 5 mg should be used, and it can be increased to 10 mg following clinical response evaluation. When increasing to 10 mg daily, pay attention to gastrointestinal adverse reactions during administration. For underweight female patients over 85 years of age.

Child dose

There is no experience with the use in children.

This medicine contains Donepezil Hydrochloride Monohydrate and is used for the treatment of Alzheimer's-type dementia. This medication should not be administered to certain patients. For example, patients who are allergic to this medication or its components, women who are pregnant or breastfeeding, and patients with genetic issues such as lactose intolerance should not take this medication. Patients with heart disease or cardiac conduction disorders should be cautious, as use of this medication may lead to cardiac issues such as bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication cautiously, as increased gastric acid secretion may exacerbate ulcers. Patients with asthma or obstructive lung disease should be cautious, as broncho-constriction and increased mucus secretion may worsen their symptoms. Patients with extrapyramidal disorders such as Parkinson's disease may face the risk of aggravating their symptoms, so caution is necessary. During treatment with this medication, serious adverse reactions may occur, including fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death. If any of these symptoms occur, immediate medical attention is essential. Additionally, various side effects such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, anxiety, depression, palpitations, rashes, muscle pain may occur, so caution is advised. This medication is not approved for use in other forms of dementia or memory impairments and should only be used by patients diagnosed with Alzheimer's-type dementia. Patients with heart disease, especially those with a history or family history of QT interval prolongation, require cardiac monitoring during the use of this medication. Since this medication may affect driving or operating machinery, caution should be taken during initial dosing or when increasing the dosage. This medication may interact with certain drugs, so if there are other medications being taken, it is essential to consult a healthcare professional. Women who are pregnant or breastfeeding are advised not to use this medication unless absolutely necessary and only after consulting a professional. The safety of this medication in children has not been established, so it should not be used in pediatric patients. In cases of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may occur, and immediate medical treatment should be sought. This medication should be stored out of the reach of children and should not be transferred to other containers.

Serious side effects

• Fainting
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal ulcer
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• tremors

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to ensure the medication remains effective and safe for use.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle