Atrasemi Tablet

Adult dose

Children aged 12 and older and adults: The dosage should be adjusted according to the patient's level of pain and treatment response. An initial dose of 4 tablets is recommended, and subsequent doses should have a minimum interval of more than 6 hours, and should not exceed 16 tablets per day. The effective minimum dose should be administered for the shortest duration possible. Avoid administering this medication for an extended period without medical necessity; if prolonged administration is necessary due to the nature and severity of the disease, regular monitoring for continued need for this medication should be conducted.

Child dose

Children aged 12 and older: The dosage should be adjusted according to the patient's level of pain and treatment response. An initial dose of 4 tablets is recommended, and subsequent doses should have a minimum interval of more than 6 hours, with a maximum of 16 tablets per day.

This medication significantly increases the risk of liver damage for individuals who regularly consume more than three alcoholic beverages daily, so it must be discussed with a doctor or pharmacist. Rarely, this medication can cause serious skin reactions, so if a rash or allergic symptoms occur, administration should be immediately stopped, and medical advice should be sought. One of the main ingredients of this medication, tramadol, can increase the risk of seizures if taken in excess of the recommended dose or with certain medications, so caution is needed. For patients with severe bronchial asthma, there is a serious risk of respiratory suppression when this medication is administered, thus it should be given only in a medically equipped environment. Taking this medication with alcohol or benzodiazepines can lead to severe drowsiness, respiratory suppression, or coma, so co-administration should be avoided. Patients with increased intracranial pressure or head injury may experience exacerbated symptoms when taking this medication, thus caution is advised. This medication may lead to physical and psychological dependence; thus, medical staff should closely monitor for dependence when used for extended periods. Patients with impaired liver function must consult a doctor before taking this medication, as there is a risk of liver damage, and the recommended dosage should not be exceeded. In particular, patients who are ultra-rapid metabolizers of CYP2D6 may rapidly increase the active metabolites of this medication, leading to serious side effect risks such as respiratory suppression, necessitating dosage adjustments and monitoring. This medication should not be administered to children younger than 12 years or adolescents under 18 years who have undergone tonsillectomy or adenoidectomy due to elevated risks of respiratory suppression in this age group. This medication can cause sleep apnea or hypoxia; symptoms should be continuously monitored and dosages should be reduced or discontinued if necessary. Electrolyte imbalances such as hyponatremia may occur, so particularly elderly patients or patients with risk factors should undergo blood tests for monitoring. Those with allergies to this medication's ingredients, those who are overdosed on central nervous system depressants, those with severe respiratory suppression, head injuries, or those currently taking MAO inhibitors should not take this medication. Sudden discontinuation while taking this medication may lead to withdrawal symptoms such as anxiety, insomnia, and irritability; thus, it is advisable to gradually taper off under medical supervision. This medication can cause drowsiness and dizziness when driving or operating machinery, so caution is advised, especially with concurrent alcohol use. Overdose may present serious symptoms such as respiratory suppression, seizures, or heart problems; in emergency situations, contact medical services immediately. This medication can interact with various other medications, so inform medical personnel about any other medications being taken, particularly antidepressants, antibiotics, and anticoagulants, as caution is particularly needed with these combinations. Elderly patients have a higher risk of side effects due to decreased liver, kidney, and heart functions as well as multiple drug use, thus usage should be done more cautiously. Pregnant or breastfeeding women must consult a doctor before taking this medication, as it can pass into breast milk and affect the baby.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory anomalies accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination.

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This medication should be stored in a sealed container to prevent air or moisture ingress and kept in a cool place below room temperature of 25 degrees Celsius. Proper storage can help maintain the effectiveness of the medication for a longer period.

Appearance

Pale yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle