Lapin Tablet (Lacidipine)

Adult dose

1. Adults The therapeutic dose of this medicine should be adjusted as appropriate according to the patient's response and severity of symptoms. The initial dose is lacidipine 2 mg once daily. Take it at the same time each day, preferably in the morning, regardless of meals. If a dose increase is needed, increase to 4 mg once daily after an appropriate period has elapsed to adequately assess the pharmacological effect. Increase to 6 mg once daily only if blood pressure is not controlled with 4 mg once daily. Except in patients who require more rapid dose escalation, the period before deciding to increase the dose should be at least 3 ～ 4 weeks, the time needed for this medicine to achieve its full pharmacological effect. If an adequate response is not obtained, another antihypertensive agent may be added (a beta-blocker and/or a diuretic). 2. Patients with hepatic impairment Because this medicine is metabolized primarily in the liver, its bioavailability and blood pressure-lowering effect may be increased in patients with hepatic impairment. These patients should be carefully monitored, and a reduced initial dose is recommended. 3. Patients with renal impairment Since this medicine is not excreted through the kidneys, dose adjustment is not necessary in patients with renal impairment. 4. Elderly patients Administer an initial dose of 2 mg once daily. If necessary, the dose may be increased to 4 mg once daily after 4 weeks.

Child dose

5. Children There is no experience with the use of this medicine in children.

This medication should not be used in certain patients. Patients who are allergic to this medication or its components, pregnant or breastfeeding women, patients with cardiogenic shock or unstable angina, patients with aortic stenosis, patients who have had a myocardial infarction within the last month, patients with left ventricular dysfunction, patients taking dantrolene, and patients with lactose intolerance or related genetic disorders should not take this medication. This medication should be administered with caution to patients with dysfunctions of the sinoatrial node or atrioventricular node, patients with insufficient cardiac reserve, patients with liver dysfunction, patients with prolonged QT interval, and patients with unstable angina. While this medication is generally well tolerated, mild side effects such as dizziness, headache, palpitations, flushing, nausea, skin rash, and edema may occur temporarily. In patients with cardiovascular diseases, angina may worsen, so caution is needed. Abrupt discontinuation of this medication can worsen symptoms, so dosages should be gradually reduced under medical supervision when stopping. Additionally, this medication can affect heart rate and blood pressure, so patients with weakened cardiac function should exercise special caution. When taken in conjunction with other antihypertensive medications, this medication may cause blood pressure to drop too low, so caution is warranted, and it is advised to consult with a doctor or pharmacist regarding potential drug interactions. Particularly, grapefruit juice should be avoided as it may influence the effectiveness of the medication. Pregnant or breastfeeding women should refrain from taking this medication, and safety in children has not been established. In case of an overdose, blood pressure drop and cardiac arrhythmias may occur, requiring immediate medical attention. This medication should be stored out of reach of children and should not be transferred to another container.

• Dizziness
• headache
• mood disorders
• tremors
• depression
• palpitations
• tachycardia
• flushing
• worsening of pre-existing angina
• syncope

This medication may deteriorate due to air or light, thus it should be stored in a sealed container. It is also important to keep it in a cool place at a temperature below 30 degrees Celsius to maintain its efficacy.

Appearance

White oval film-coated tablet

Package unit

90 tablets (10/PTPX9)