Clopidogrel Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, 75 mg of clopidogrel is administered orally once daily. For patients with acute coronary syndrome (unstable angina or non-ST segment elevation myocardial infarction), initiate with a loading dose of 300 mg orally once daily on the first day of treatment, followed by a maintenance dose of 75 mg orally once daily. In this case, aspirin 75-325 mg should be taken orally once daily in conjunction with this medication.

This drug acts as an active metabolite to prevent platelets from aggregating, thereby preventing thrombus formation. Patients with genetically reduced function of a specific enzyme (CYP2C19) may experience decreased efficacy of this drug; in such cases, treatment adjustments should be made. Co-administration with drugs that activate this enzyme may increase drug levels and elevate the risk of bleeding, so co-administration should be avoided. This drug should not be given to patients with a known allergy to this drug or its components, those with bleeding issues, severe liver impairment, nursing women, or patients with certain genetic lactose intolerance. Patients with a high risk of bleeding, impaired liver or kidney function, recent stroke, hypertension, the elderly, etc., should use this medication with caution, and it may be necessary to stop administration before surgery after consulting with a physician. This drug may prolong bleeding time and increase the risk of bleeding; thus, patients should inform their doctor immediately if any bleeding symptoms occur. Care should be taken when co-administering with other bleeding risk medications, anticoagulants, antiplatelet agents, and some antidepressants. During pregnancy, the risk of bleeding may increase; thus, use should be determined at the physician's discretion, and if breastfeeding, a decision must be made regarding whether to discontinue nursing due to the possibility of drug excretion into breast milk. Safety in children has not been established, and the elderly may experience adverse reactions such as bleeding due to declining body function and should be monitored closely. Overdose may increase the risk of bleeding; if necessary, platelet transfusions can reverse the effects. While taking this medication, patients should be aware of potential adverse reactions such as bleeding symptoms, rash, headache, dyspepsia, etc., and consult healthcare professionals if any symptoms arise. Additionally, this medication should be kept out of reach of children and should not be transferred into other containers for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, shortness of breath, cold sweat, pallor, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, difficulty breathing or shortness of breath, asthma attack, respiratory disturbances with cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination troubles

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• pruritus
• purpura/contusion
• epistaxis

This drug should be stored in an airtight container to protect it from air and moisture and kept at room temperature between 1°C and 30°C. Storing it this way will maintain its effectiveness and prevent degradation.

Appearance

Pink round film-coated tablets

Package unit

30, 300 tablets/bottle