Green Cross Heparin Sodium Injection

Adult administration

Typically administered intravenously or added to perfusion blood during extracorporeal circulation. Effects appear immediately after administration, but sensitivity to heparin varies greatly among individuals, so a sensitivity test should be performed before administration, and coagulation time should be measured after administration to determine the maintenance dosage. 1. Extracorporeal circulation 1) Artificial kidney (1) Systemic heparinization: 1,000 to 5,000 IU of heparin sodium is administered before dialysis begins.

This medication is very powerful, so it must only be used under the thorough supervision of a doctor. Caution should be exercised when administering to patients with a high risk of bleeding, as bleeding can occur in almost any part of the body following administration. Serious bleeding can occur rarely, so vigilance is necessary. Additionally, this medication contains benzyl alcohol, which can cause life-threatening respiratory problems in premature infants or newborns, so it should not be administered to them. Patients with hypersensitivity to this medication, inappropriate blood coagulation test results, tendencies for bleeding, severe liver or kidney disease, recent surgery or trauma, those who have received spinal and epidural anesthesia, those with a history of specific thrombocytopenia, neonates, and prematures should not use this medication. Patients with consumptive coagulopathy, those with catheters in place, pregnant individuals in the late stages of pregnancy, individuals with severe retinal diseases, liver or kidney dysfunction, elderly individuals, and those with alcohol dependence should use this medication cautiously and have their blood coagulation status monitored regularly. This medication may cause side effects such as bleeding, thrombocytopenia, liver dysfunction, hypersensitivity, skin abnormalities, and osteoporosis with prolonged use, so any abnormal symptoms should be reported to healthcare personnel immediately. Management of bleeding risk should be done through blood coagulation tests, and administration should be discontinued in cases of severe bleeding or thrombocytopenia. If thrombocytopenia occurs, the risk of serious thrombosis is high, so this medication should be stopped immediately, and alternative treatment should be considered. There are many drug interactions with this medication, so the risk of bleeding may increase when used with acetylsalicylic acid, nonsteroidal anti-inflammatory drugs, anticoagulants, etc., so consultation with healthcare personnel is essential. Women who are pregnant or breastfeeding should consult a doctor before using this medication, and particular caution is needed during childbirth due to a high risk of bleeding. Safety in children has not been established sufficiently, and caution should be exercised in the elderly due to a high risk of bleeding. In case of overdose, the risk of bleeding significantly increases, so immediate administration of the antidote protamine sulfate is necessary, and caution regarding side effects is needed even when using the antidote. During treatment, intramuscular injections should be avoided, and mixed injections with antihistamines should not be done.

Serious side effects

Urticaria, angioedema, shock, bleeding, adrenal hemorrhage, ovarian hemorrhage, retroperitoneal hemorrhage, dyspnea, cyanosis, thrombocytopenia, acute reversible thrombocytopenic purpura, thrombosis, heparin-induced thrombocytopenia (HIT) and thrombosis (HITT), vascular spasm reactions, vascular disorders, thrombosis due to thrombocytopenia, severe allergic reactions, severe bleeding, renal impairment, liver impairment, jaundice, severe neurological symptoms associated with thrombocytopenia

Mild side effects

• Itching
• chills
• fever
• rhinitis
• tearing
• conjunctivitis
• tachycardia
• pressure
• nausea
• vomiting

This medication should be stored in a tightly closed container that blocks light, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy of the medication for a longer period.

Appearance

A colorless or pale yellow transparent liquid in a brown vial.

Package unit

10 vials/box [(vial (5 milliliters))]