Glucera Tablets 500 mg (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug efficacy and tolerability and should not exceed the recommended maximum daily dosage. This medication must be started at a low dose to reduce gastrointestinal adverse reactions and to confirm the minimum effective dose necessary for adequate blood sugar control, administered in divided doses of 500 mg two to three times daily with meals. The dosage can be gradually increased by 500 mg weekly, up to 20.

Child dose

Can be used in children aged 10 years and older. The usual starting dose is 500 milligrams once daily, taken during or after meals. Check blood sugar levels after one week to adjust the dosage.

This medication can cause severe lactic acidosis or hypoglycemia and should not be used, especially in patients with impaired kidney function or acute conditions such as infection and heart failure. It should not be administered to patients with moderate to severe kidney impairment, dehydration, serious infection, or acute myocardial infarction, which may affect kidney function. Patients with acute or unstable heart failure, those undergoing radiologic iodine contrast examinations, and those with hypersensitivity to this medication or similar drugs should also not be treated with it. This medication is not to be used in patients with type 1 diabetes or those with diabetic ketoacidosis or diabetic pre-coma. Patients with severe infections or serious trauma causing systemic disorders should discontinue this medication until oral intake recovers and kidney function normalizes. Patients scheduled for surgery should stop this medication 48 hours prior to surgery and restart only after confirming normal kidney function post-surgery. This medication should be used with caution in cases of malnutrition, starvation, weakness, pituitary dysfunction, or adrenal insufficiency. Patients with liver dysfunction or pulmonary dysfunction, those consuming excessive alcohol, or those experiencing dehydration, diarrhea, or vomiting require careful monitoring when using this medication. This medication may rarely cause lactic acidosis, which can be fatal, so both patients and healthcare providers should closely monitor for symptoms of lactic acidosis such as fatigue, muscle pain, difficulty breathing, weakness, and abdominal pain. During treatment, gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal distension may occur, generally transient, but dosage adjustment may be necessary if severe. This medication lowers blood sugar but carries a risk of hypoglycemia, especially when used with other antidiabetic agents or when food intake is insufficient, necessitating caution. If kidney function is decreased, this medication can accumulate in the body, increasing the risk of side effects; thus, regular kidney function tests should be conducted before and during treatment. Alcohol can affect the metabolism of this medication, increasing the risk of lactic acidosis, so excessive drinking should be avoided during treatment. In pregnant women, this medication can cross the placenta and affect the fetus. It should be avoided in cases where there is a risk of placental insufficiency or pre-eclampsia and used cautiously only when blood sugar control is critically needed during pregnancy. Breastfeeding women should carefully decide whether to continue breastfeeding or discontinue the medication, as this medication is excreted in breast milk. Elderly individuals commonly experience reduced kidney function; therefore, treatment should start at the minimum dosage, with regular monitoring of kidney function and avoidance of maximum dosage. In case of overdose, blood dialysis can remove the drug, so patients should immediately inform healthcare providers and receive appropriate treatment. This medication interacts with various other drugs; therefore, if patients are taking other medications, they should inform their healthcare providers, and blood sugar changes and patients' conditions must be monitored closely. During treatment, regular meals and exercise, along with periodic blood sugar and kidney function testing, are crucial, and patients should consult healthcare providers immediately if any abnormal symptoms occur.

Serious side effects

Lactic acidosis (specifically, fatigue, muscle pain, difficulty breathing, weakness, abdominal pain, low body temperature, low blood pressure, resistant bradyarrhythmia), severe allergic reactions (hives, severe swelling), severe skin reactions (severe rash, blisters, skin peeling, pain in mouth/eye mucosa), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanying breathing abnormalities), liver issues (yellowing of skin or eyes, systemic symptoms).

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), unpleasant or metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, delayed hypoglycemia.

Store this medication in a tightly closed container to prevent air and moisture exposure. Additionally, when storing the medication, it is important to maintain a temperature between 1°C and 30°C.

Appearance

White round film-coated tablet

Package unit

300 tablets/bottle