Neoami Injection

Adult dosage

In chronic renal failure for peripheral vein administration, generally, adults receive 200 mL slowly via intravenous drip once daily. The administration rate is based on 120-180 minutes for 200 mL (approximately 25-15 drops per minute), with slower infusion rates recommended for the elderly and severely ill patients. During dialysis procedures, it should be administered 90-60 minutes before the end of dialysis via the venous side of the dialysis circuit. In cases of high-calorie intravenous therapy, it is administered.

Children's dosage

The infusion rate for children should be slower than the standard 120-180 minutes for 200 mL, similar to the rate used for the elderly and severely ill patients.

This drug must be used only as directed by a physician. It should not be used in patients at risk of hepatic coma or hepatic coma itself, as this drug may cause an imbalance of amino acids and worsen the hepatic coma. Patients with hyperammonemia should also avoid using this drug. The condition may worsen due to nitrogen overload. It should not be administered to patients with congenital amino acid metabolism disorders, as the administered amino acids may not be metabolized properly, worsening symptoms. Patients with heart or circulatory problems should use this drug with caution, as it may increase blood volume and put stress on the heart, potentially worsening symptoms. Patients with liver dysfunction or gastrointestinal bleeding should also exercise caution, as excessive accumulation of amino acids may lead to hyperammonemia. Patients with electrolyte imbalances or acid-base equilibrium disorders should be careful, as symptoms may worsen with the use of this drug. This drug contains sodium bisulfite, which may cause allergic reactions. Patients with asthma are particularly sensitive to sulfites, so caution is needed. If hypersensitivity reactions such as itching, rash, or hives occur during use, administration must be stopped immediately. Gastrointestinal symptoms such as nausea, vomiting, and loss of appetite may occur, along with cardiovascular symptoms such as chest discomfort or palpitations. Rapid and high administration can cause metabolic acidosis, so the administration rate must be adjusted slowly. Headache, nasal congestion, metabolic acidosis, elevated liver function tests, and in some cases, symptoms such as chills, fever, and vascular pain may also occur. It is used when oral nutrition intake is difficult or in situations requiring parenteral nutritional management. In patients with renal failure, the use of essential amino acid preparations alone has been reported to cause hyperammonemia and altered consciousness, so close monitoring of the patient's condition is required. Women who are pregnant or may become pregnant should use it only when the benefits of treatment outweigh the risks. Safety in pediatric populations has not been established, so there is no experience in using it for children. Elderly patients may have reduced physical functions, so caution should be taken to administer slowly and adjust doses accordingly. Before administration, ensure that the solution is completely clear, and if crystallization occurs, it should be dissolved at 50-60 degrees and cooled to body temperature before use. After opening, it should be used quickly, and any remaining solution should never be reused. In chronic renal failure patients who are not on dialysis, the dosage of this drug should be adjusted considering the amount of dietary protein intake. This drug contains sodium and acetate, so caution regarding electrolyte balance is needed during large-volume administration. The administration rate should be slow, as a rapid injection may cause chills or vomiting, and the loss of amino acids through the kidneys may worsen. During storage, do not use if the aluminum cap is removed, the solution is discolored, or if there is leakage, and be careful to prevent discoloration of the solution until the packaging is opened.

Serious side effects

Severe allergic reactions such as anaphylaxis, asthma attacks

Mild side effects

• Generalized itching
• rash
• generalized urticaria
• nausea
• vomiting
• loss of appetite
• chest discomfort
• palpitations
• headache
• nasal congestion

This drug should be stored in a sealed container to prevent air and moisture from entering, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the drug's effectiveness for a long time.

Appearance

This drug is a colorless to pale yellow transparent injection filled in a polypropylene aqueous injection container.

Package unit

250 milliliters/box