OK Sol Injection

Adult dosage

Adults (based on a 70 kg patient): Administer 1000-1500 mL by intravenous drip infusion daily. Administration rate: Administer 2 mL per kg of body weight over 60 minutes (45 drops per minute). However, the maximum daily dosage is 100 g of D-Sorbitol.

This medication must be used strictly according to a doctor's instructions. It should not be administered to patients with severe renal impairment, hyperazotemia, liver dysfunction, or issues with amino acid metabolism. It is also contraindicated in patients with heart failure, pulmonary edema, oliguria, anuria, heart block, myasthenia gravis, children, pregnant women, and those with specific metabolic disorders or acidosis, or dehydration due to storage disease. Administration should be avoided in patients with myocardial infarction, renal failure, and those with inadequate cell oxygen supply. Caution should be exercised when administering to patients with congestive heart failure, edema due to sodium retention, hyperkalemia, renal impairment, or diabetes insipidus. Rarely, hypersensitivity reactions such as rashes may occur when using this medication, along with gastrointestinal symptoms such as nausea or vomiting. Cardiovascular symptoms like chest discomfort, palpitations, rapid heartbeat, or increased blood pressure may also occur, requiring caution. Rapid large volume administration may cause acidosis, and a variety of side effects like heat sensation, chills, fever, headache, and difficulty breathing may manifest. Metabolic complications may include acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin imbalance, and electrolyte disturbances. Patients with renal failure should be cautious as blood BUN levels may increase. When large doses are administered or used in conjunction with electrolyte solutions, careful attention to electrolyte balance is necessary. Overdose may lead to metabolic alkalosis, particularly with products containing acetate ions. In patients with kidney, lung, or heart diseases, care must be taken to avoid excessive fluid changes during administration. Diabetic patients should check their blood glucose levels frequently while using this medication. Interactions may occur when used with other medications, especially when co-administered with tetracycline antibiotics and calcium salts. Safety for pregnant women has not been established; therefore, it should only be administered when absolutely necessary. Children may have immature liver function, so lower doses should be given while closely monitoring blood ammonia levels. Elderly patients have decreased physical function, necessitating slower administration rates and dose adjustments. This medication contains electrolytes, so caution is required for electrolyte balance when administered in large quantities, and should be slowly injected intravenously. Rapid administration may cause chills or vomiting. The solution should be used at body temperature and must be prepared and managed under aseptic conditions; discolored or abnormal solutions should not be used. In cases where the formulation includes xylitol, care should be taken regarding the rate and amount of administration to avoid burdening the kidneys and liver. During storage, no venting needle is required, and vial products must have the venting needle punctured just before use. Do not use if the packaging is damaged or the solution is discolored, and use must adhere to the markings on the container.

Serious side effects

Severe allergic reactions (hives, severe swelling), difficulty breathing, respiratory failure, shock, bronchospasm, pulmonary edema, oliguria, anuria, renal failure, severe edema associated with hypertension.

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• rapid heartbeat (tachycardia)
• increased blood pressure
• acidosis
• heat sensation
• vascular pain

This medication should be stored in a tightly sealed container to prevent exposure to air and is recommended to be kept at room temperature. This helps maintain the drug's effectiveness and prevents degradation.

Appearance

It is an injectable solution filled in a colorless to light yellow transparent liquid in a colorless transparent glass container with a rubber stopper for infusion.

Package unit

250mL/bottle