Brenosol Injection

Adult dosage

For peripheral venous administration: 200 to 400 mL is administered via slow intravenous drip. Administration speed: Approximately 120 minutes for 200 mL (about 25 drops per minute). In terms of total amino acid quantity, approximately 10 g over 60 minutes is preferred for body utilization. For central venous administration: 400 to 800 mL is continuously infused through a central vein using high-calorie liquid methods, adjusted according to age, symptoms, and body weight.

Children's dosage

For peripheral venous administration: slowly infuse in children, the elderly, and severely ill patients.

This medication should always be used according to a doctor's instructions. It should not be used in patients who are in a state of hepatic coma or at risk for it. Patients with severe kidney dysfunction or high blood nitrogen levels should also not receive this medication. Patients with nitrogen metabolism issues, severe heart failure, and pulmonary edema should avoid using this medication. Patients with very low or absent urine output should also not receive it. Patients with abnormally high blood sodium or chloride levels should be cautious due to potential issues caused by the ions included in this medication. Patients in a state of severe acidosis, those with congestive heart failure, edema due to sodium retention, and those with hyperkalemia should use this medication cautiously. Special caution is needed when administering to patients with impaired liver or kidney function. This medication contains sodium bisulfite, which can cause severe allergic reactions in individuals allergic to sulfites, particularly asthmatics, so care should be taken. If a rash or other hypersensitivity reactions occur while using this medication, administration should be stopped immediately. Symptoms like nausea, vomiting, chest discomfort, palpitations, and increased blood pressure may occur. Rapid administration in large volumes can lead to acidosis, so caution is advised. Serious side effects like chills, fever, headache, and difficulty breathing may rarely occur. Metabolic abnormalities can lead to increased blood sugar, electrolyte imbalances, and vitamin deficiencies, especially in patients with weakened liver or kidney function who need to have their condition checked frequently with blood tests. Electrolyte balance should be well monitored when administering large amounts of this medication or using it in conjunction with electrolyte-containing solutions. Excess dosing may lead to metabolic alkalosis, so this should be monitored. Patients with heart, lung, or kidney diseases should control the speed and amount of administration to prevent complications from fluid overload. Diabetic patients should measure their blood sugar frequently while using this medication. This medication may reduce the efficacy when used with certain antibiotics; therefore, consult a doctor before co-administration. Pregnant women should use this medication only under a doctor's judgment since its safety has not been established. Children may have immature liver function, so it should be administered in lower concentrations and blood ammonia levels should be checked frequently. Elderly patients may have decreased physiological function; therefore, administration speed should be slower and dosages adjusted. This medication contains electrolytes, and rapid infusion can result in chills or vomiting; thus, it should be slowly administered intravenously. During the preparation and management of infusion solutions, strict aseptic techniques should be maintained to reduce infection risks. If the solution is discolored or cloudy, do not use it, and adhere to specified storage temperatures and durations. Before use, carefully check the condition of the container, and do not administer if it is damaged.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, pallor → severe allergic reaction
• Severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa → severe skin reaction
• Difficulty breathing, respiratory arrest, shock, bronchospasm → respiratory issues
• Severe edema or urination problems (significantly reduced urine output, general severe swelling, including elevated blood pressure)

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• tachycardia
• increased blood pressure
• metabolic acidosis
• hypophosphatemia
• alkalosis

This medication should be stored in a sealed container to protect it from air and moisture exposure. The recommended storage temperature is between 1 and 30 degrees Celsius at room temperature.

Appearance

A transparent solution that is colorless to pale yellow contained in a polypropylene aqueous injection vial.

Package unit

250mL/box