Medication info

Fluorosulfide Hepa Injection

Prescription medicationInjections
Ingredient · strength
L-Proline›6000mg / 1000mLL-Histidine›1875mg / 1000mLL-Valine›6300mg / 1000mLAcetylcysteine›337mg / 1000mLL-Alanine›5475mg / 1000mLL-Serine›3450mg / 1000mLL-Phenylalanine›600mg / 1000mLL-Threonine›3375mg / 1000mLL-Isoleucine›6775mg / 1000mLL-Methionine›450mg / 1000mLL-Leucine›8275mg / 1000mLGlycine›6750mg / 1000mLL-Arginine›4500mg / 1000mLL-Tryptophan›375mg / 1000mLL-Lysine Hydrochloride›6934mg / 1000mL
Manufacturer / importer
에이치케이이노엔(주)
Appearance
A transparent, colorless or pale yellow transparent injectable solution filled in a colorless, transparent plastic container.
Packaging
100, 250 milliliters
Approval status
Active

MFDS item code 199301540 · Notified 1993.05.31

Summary

Main use
Improvement of encephalopathy due to acute and chronic liver dysfunction and amino acid supply effect.
Who uses it
Adults · Children
Adult dosage
As a total amino acid, infuse intravenously at a maximum dosage of 1-1.5 g per kg of body weight daily. An infusion rate of a total amino acid concentration of approximately 10 g over 60 minutes is desirable; it is principle to infuse at a rate of 30-40 drops per minute.
Children's dosage
Dosage and infusion rate for children must be adjusted appropriately.

Ingredients

Manufacturer
에이치케이이노엔(주)

Efficacy & effects

Improvement of encephalopathy due to acute and chronic liver dysfunction and amino acid supply effect.

View approved original text

This medication is used to improve the symptoms of encephalopathy caused by acute and chronic liver dysfunction and to supplement amino acids needed by patients with liver dysfunction. This helps in the recovery of liver function and improvement of neurological status.

Dosage and Administration

Adult dosage

As a total amino acid, infuse intravenously at a maximum dosage of 1-1.5 g per kg of body weight daily. An infusion rate of a total amino acid concentration of approximately 10 g over 60 minutes is desirable; it is principle to infuse at a rate of 30-40 drops per minute.

Children's dosage

Dosage and infusion rate for children must be adjusted appropriately.

Precautions

This medicine must be used according to a doctor's instructions. It is safe not to use this medication in patients with severe renal impairment or hyperazotemia. Additionally, it should not be administered to patients with problems in amino acid metabolism, as well as those with metabolic diseases that impair nitrogen utilization or patients with severe heart failure or pulmonary edema. Caution is necessary for patients with very low or absent urine volume, high sodium and chloride levels, and those with atrioventricular block or severe myasthenia gravis. Administration is not recommended in patients with excessive water supply. The medication should be used cautiously in patients with severe acidosis, heart failure, edema due to sodium retention, hyperkalemia, and those with reduced kidney function. Rarely, hypersensitivity reactions like skin rashes may occur, and administration should be stopped immediately if symptoms arise. Gastrointestinal symptoms like nausea or vomiting, chest discomfort, or rapid heart rate may occur. Rapid administration of large volumes may lead to acidosis, so caution is required. Symptoms such as chills, fever, headache, and respiratory distress have also been reported. If magnesium is included, peripheral blood vessels may dilate, so caution is needed. Various metabolic complications such as metabolic acidosis, hypophosphatemia, hyperglycemia, and electrolyte imbalances may occur. Patients with severely impaired liver or kidney function may experience elevated waste levels in the blood, requiring close monitoring of their condition. When administering large doses of this medication or using it with other electrolyte-containing fluids, particular attention should be paid to electrolyte balance. Overdosage may cause metabolic alkalosis, so the dosage should be carefully adjusted based on the constituents included. Diabetic patients should regularly check their blood glucose levels during administration. Patients with kidney, lung, or heart diseases need to be cautious to avoid excessive body fluid increases. This medication can interact with other medications, especially when used with tetracycline antibiotics, calcium salts, or vitamin B1, hence consultation with a professional is necessary. Its safety has not been established in pregnant women, so it should only be used when the benefits of treatment outweigh the risks. For children, the concentration should be lowered due to possible immature liver function, and blood ammonia levels should be regularly checked. Elderly individuals may have decreased bodily functions, so administration rates should be slow, and dosages should be adjusted. This medication contains electrolytes, so electrolyte balance must always be checked during administration, and administration should be done slowly to avoid side effects. Before use, ensure the solution is clear and transparent, and do not use if it is discolored or abnormal.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, pallor, severe allergic reactions, severe rashes, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, severe skin reactions, difficulty breathing, asthma attacks, cough accompanied by fever, respiratory abnormalities, jaundice, severe lethargy, liver dysfunction (jaundice), significant edema or urination abnormalities, shortness of breath or difficulty breathing, respiratory arrest, shock.

Mild side effects

  • Rash
  • nausea
  • vomiting
  • chest discomfort
  • palpitations
  • tachycardia (rapid heartbeat)
  • elevated blood pressure
  • chills
  • fever
  • headache
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  • peripheral vascular dilation
  • metabolic acidosis
  • hypophosphatemia
  • alkalosis
  • hyperglycemia
  • diabetes
  • osmotic diuresis and dehydration
  • rebound hypoglycemia
  • elevated liver enzymes
  • vitamin deficiency and excess
  • electrolyte imbalance
  • pediatric hyperammonemia
  • serum amino acid imbalance
  • metabolic alkalosis
  • systemic nitrogen retention
  • hyperammonemia.

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to prevent air or moisture infiltration, and it is advisable to keep it at room temperature away from direct sunlight. By maintaining appropriate storage methods, the efficacy of the medication can be preserved for a long time.

Appearance and packaging

Appearance

A transparent, colorless or pale yellow transparent injectable solution filled in a colorless, transparent plastic container.

Package unit

100, 250 milliliters

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.