Anosol Injection

Adult dosage

For adults, a maximum dosage of 1 to 1.5 g per kg of body weight per day of total amino acids should be administered by infusion. The infusion rate should ideally be a total amino acid concentration of about 10 g over 60 minutes, with infusion being performed at a rate of 30 to 40 drops per minute.

Children's dosage

Dosing and infusion speed should be adjusted for children.

This medication must be used strictly under a doctor's guidance. It should not be administered to patients in hepatic coma or at risk of hepatic coma. Patients with severe renal impairment or hypernitrogenemia should also avoid this medication. It is not suitable for patients with metabolic disorders affecting nitrogen utilization. This medication should not be administered to patients with severe congestive heart failure or pulmonary edema. Patients with negligible or no urine output should not use this medication. In cases where sodium or chloride ions are included, it should not be given to patients with hypernatremia, hyperchloremia, or alkalosis. Patients with severe acidosis, congestive heart failure, edema due to sodium retention, or hyperkalemia or potassium retention should use it with caution. Patients with compromised liver or kidney function also need care. As sodium bisulfite is included, individuals allergic to sulfites or asthmatic patients may experience severe allergic reactions, so care is needed. Rarely, skin rashes and other hypersensitivity reactions may occur, and in such cases, use should be discontinued immediately. Gastrointestinal symptoms such as nausea or vomiting may occur. Cardiac symptoms like chest discomfort, palpitations, rapid pulse, and increased blood pressure may occur. Rapid administration of large amounts may lead to acidosis. Chills, fever, headache, shortness of breath, shock, bronchospasm, and urinary spasms may occur. Metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin deficiencies or excesses, and electrolyte imbalances may present. Patients with compromised liver or kidney function may experience increased blood urea nitrogen levels. Patients with severely impaired liver function may present with amino acid imbalance in the blood, metabolic alkalosis, and coma among other severe symptoms. In cases of large doses, attention must be paid to electrolyte balance, and it should be used with caution when used with electrolyte-containing solutions. Overdosage may lead to metabolic alkalosis, so care is necessary. Patients with kidney disease, lung disease, or severe heart disease should adjust dosage and infusion speed to prevent fluid overload. Diabetic patients should check their blood sugar levels frequently while using this medication. When used together with the specific antibiotic tetracycline, the protein-sparing effect of this medication may be reduced, so caution is advised. The safety for pregnant women has not been established, so it should only be administered when the benefits of treatment outweigh the risks. In children, the dosage and infusion speed should be adjusted, and ammonia levels in the blood checked frequently due to the risk of hyperammonemia because liver function is not fully developed. Elderly patients should have the infusion speed decreased and dosage adjusted due to declining bodily functions, and care should be taken. This medication contains electrolytes, so care must be given to electrolyte balance during high-volume administration, and the intravenous infusion speed should be slow. Rapid infusion may result in chills, vomiting, and increased amino acid loss to the kidneys. Infusion fluids should be warmed to body temperature before use, and a sterile environment should be strictly maintained during preparation and management. Before administration, check that the solution is clear and without abnormalities, and use promptly after mixing. During storage, keep sealed without opening the packaging, and do not use if the solution has changed color or leaked. Patients with a history of myocardial infarction should not use this medication.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reactions), severe rash, blisters, skin peeling, oral/eye mucosal pain (severe skin adverse reactions), respiratory distress, respiratory arrest, asthma attacks, shock, bronchospasm (breathing problems), jaundice, extreme somnolence (liver dysfunction), sudden and very severe headaches, confusion, visual disturbances, paralysis (serious neurologic symptoms).

Mild side effects

Rarely, hypersensitivity symptoms such as rash, gastrointestinal symptoms like nausea and vomiting, circulatory symptoms like chest discomfort, palpitations, rapid pulse (tachycardia), and elevation of blood pressure may occur. Rapid infusion of large volumes may lead to acidosis, chills, fever, headache, shock, urinary spasms, metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, osmotic diuresis, dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin deficiency and excess, electrolyte imbalances, and childhood hyperammonemia.

This medication should be stored in a sealed container to prevent exposure to air or moisture at room temperature. Avoid extremely hot or cold places and store it in a cool place away from direct sunlight.

Appearance

A transparent injection containing a colorless to pale yellow solution.

Package unit

100 milliliters/vial, 250 milliliters/vial