Vincristine Injection (Vincristine Sulfate)

Key information summary

Efficacy & effects

This drug is used in combination with other cancer medications for the treatment of various types of cancers such as acute leukemia, Hodgkin's disease, lymphosarcoma, reticuloendothelioma, neuroblastoma, rhabdomyosarcoma, and Wilms tumor. This combination therapy acts effectively tailored to each cancer type and helps improve the success rate of patient treatment. Therefore, this drug plays an important role in the treatment of several types of cancer.

Dosage

The standard dose is 1.4 mg/m² of vincristine sulfate. The injection of this drug should be given within 1 minute, either by direct intravenous injection or mixed with the intravenous fluid it is being administered alongside. This drug is given intravenously every week. A 50% dose reduction is recommended for patients with liver impairment. It should not be administered in cases of severe neurotoxicity like paralytic ileus, and once neurotoxicity decreases, it can be given at 50% of the standard dose.

Precautions

This drug should not be used in patients with a history of severe hypersensitivity or specific neurological disorders. It should not be administered to pregnant or breastfeeding women as it may harm the fetus or infant. Special care should be taken when administering this drug to patients with decreased liver or kidney function, weakened bone marrow function, and those with infections. Close monitoring is required when administered to children or the elderly, as adverse reactions may be more severe. This drug can cause various side effects in several organs, including the nervous system, blood, digestive system, and cardiovascular system, so it is important to carefully check the patient's condition before and during administration. If any neurological symptoms or bone marrow suppression symptoms appear, immediate dosage adjustment or discontinuation should be considered. This drug must be administered intravenously under medical supervision, as improper administration can pose serious risks. When combined with other medications, side effects may be exacerbated due to interactions, so it is essential to inform about any other medications being taken. In case of overdose, immediate emergency treatment is necessary, and measures such as fluid management, administration of anticonvulsants, and prevention of bowel obstruction should be taken according to the symptoms. Care should be taken to avoid contact with eyes while handling this drug, and if contact occurs, rinse immediately with clean water. For storage, keep away from direct sunlight and refrigerate, and it is safest to use as soon as possible after preparation.

Side effects

Urticaria, angioedema, dyspnea, severe rash with high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, jaundice, extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output, severe systemic edema, increased blood pressure, myocardial infarction, angina, ischemic findings on ECG, sepsis, pneumonia, organ hemorrhage, granulocytopenia, bleeding tendency, intestinal obstruction

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