Sanjin Naloxone Hydrochloride Injection

Key information summary

Efficacy & effects

This medication is used to fully or partially reverse respiratory depression caused by natural and synthetic opioids, propoxyphene, methadone, and other opioid analgesics. It is also useful for diagnosis in cases of acute opioid overdose. Due to this functionality, it is very effective in quickly improving dangerous respiratory failure due to opioid overdose.

Dosage

Naloxone hydrochloride is administered intravenously, intramuscularly, or subcutaneously. The initial intravenous dose ranges from 0.4 to 2 mg. If respiratory function does not improve, it may be repeated intravenously at intervals of 2 to 3 minutes. If intravenous administration is difficult, intramuscular or subcutaneous injections may be used. During surgeries with opioid suppression, doses of 0.1 to 0.2 mg may be administered intravenously at intervals of 2 to 3 minutes, with repeated dosing within intervals of 1 to 2 hours.

Precautions

This medication is provided in glass ampoules, so care should be taken when opening the container to avoid glass fragments from contaminating the solution. Special caution is required when administering to children or the elderly. Patients with allergies to this medication or its components, or who have had hypersensitivity reactions, should not use this medication. It should also not be administered to patients taking central nervous system depressants such as barbiturates or those with respiratory depression. Patients with hypertension or heart disease should be cautious when using this medication, as it may cause sudden increases in blood pressure or rapid heart rates. Individuals with renal failure or liver disease should also exercise caution when using this medication. Side effects may include increased blood pressure, rapid heart rate, chest discomfort, tremors, post-operative pain, nausea, abdominal pain, and liver function abnormalities. Rarely, serious side effects such as sweating, seizures, and cardiac arrest may occur. Excessive use after surgery may cause pain reversal or a state of excitement, and there is a risk of cardiovascular issues such as hypotension or pulmonary edema in patients with heart disease. Seizures may occur rarely. After administration of this medication, emergency measures such as maintaining the airway, artificial respiration, and heart massage may be needed, and vasopressors may also be used. Extra caution is required for patients with heart conditions or those taking heart-affected medications, and if symptoms of pulmonary edema appear, administration should be stopped immediately, and appropriate treatment should be obtained. This medication can prolong the action time of opioid analgesics, so respiratory depression may recur, making continuous observation of the patient necessary after administration, with repeated dosing if needed. While the analgesic effect may diminish, the effect in alleviating respiratory depression is stronger. In neonates born to mothers with opioid dependence or potential for such, acute withdrawal symptoms may appear, necessitating careful use. The safety of this medication in pregnant women has not been established and should only be administered if the therapeutic benefits are considered to outweigh the risks. It is advisable to avoid administration to breastfeeding women, and if unavoidable, breastfeeding should be discontinued.

Side effects

Seizures, pulmonary edema

Alternatives / Same-ingredient medications

• Samjin Naloxone Hydrochloride Injection 2 mg

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• BC Naloxone Hydrochloride Injection 2 mg

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• Nalsun (Naloxone Hydrochloride)

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