Valdipin Plus Tablet 5/80/12.5 mg (Amlodipine, Valsartan, Chlorthalidone)

Adult dose

Take one tablet once daily with water, with or without food. It is recommended to take it at the same time each day (e.g., in the morning) if possible. For patients whose blood pressure is not controlled with amlodipine/valsartan combination therapy, this medication at 5/80/12.5 mg may be administered, and dosage can be adjusted at intervals of more than 2 weeks based on the patient's blood pressure response. The maximum recommended dose of this medication is 10/160/25 mg.

This medication may pose a serious risk to the fetus and newborn if taken during pregnancy, particularly in the second and third trimesters; therefore, treatment should be discontinued immediately upon confirmation of pregnancy. Patients with impaired liver function or progressive liver disease should be cautious as electrolyte and fluid balance may be altered, which could result in severe symptoms such as hepatic coma. Patients with severe kidney disease should use this medication cautiously, as one of its components, a diuretic, may strain kidney function, increasing the risk of uremia. Patients who are allergic to any ingredients included in this medication or have certain severe liver or kidney diseases, hypotension, pregnant women, and breastfeeding mothers should avoid its use. Especially, patients with severe hypotension, certain heart valve diseases, shock, anuria, or electrolyte imbalances in the blood should not use this medication. Patients with sodium or fluid depletion must normalize their condition before starting this medication and should seek immediate help if symptoms of hypotension occur during treatment. Patients with elevated serum potassium levels or at risk of hyperkalemia should frequently monitor potassium levels when taking this medication along with potassium supplements. Patients with cardiovascular diseases, such as heart failure, myocardial infarction, kidney transplant patients, and those with acute myocardial infarction should be closely monitored while taking this medication. Side effects such as dizziness, headaches, or decreased blood pressure may occur, so caution is needed when driving or operating machinery. Regular monitoring of liver function, kidney function, and electrolyte levels should be conducted during treatment to check for abnormalities. When combined with other medications, interactions may alter efficacy or increase the risk of side effects; therefore, inform your healthcare provider of any medications you are currently taking. In case of overdose, symptoms such as hypotension, shock, and consciousness disturbances may occur; immediate medical attention should be sought, and blood pressure and heart status should be closely monitored in emergencies. Keep this medication out of reach of children and store it in a sealed container, avoiding moisture, heat, and direct sunlight. This medication is not recommended for children under 18 years of age as its safety and effectiveness have not been established. Elderly patients may be more susceptible to dehydration, hypotension, and electrolyte imbalances, so treatment should be started at a lower dose and closely monitored.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in oral/corneal mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, cough with fever-related respiratory issues, respiratory problems, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice)

Mild side effects

Dizziness, headaches, increased blood uric acid, elevated alanine aminotransferase (ALT), elevated aspartate aminotransferase (AST), increased creatine phosphokinase (CPK), elevated blood glucose, increased triglycerides, COVID-19, nasopharyngitis, upper respiratory tract infection, eyelid twitching, orthostatic hypotension, chest discomfort, flushing, fatigue, edema, palpitations, vertigo, drowsiness, abdominal pain, nausea, weakness, lethargy, pain

This medication should be stored in a tightly sealed container to protect it from air and moisture and at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and prevent degradation.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets / bottle