Briveta 100 mg (Brivaracetam)

Adult dose

Take this medicine twice daily. The recommended initial dose is 25mg or 50mg per dose, based on the healthcare provider’s assessment of the potential side effects in relation to seizure reduction. Based on clinical response and tolerability, the dose may be increased or decreased from 50mg per day[25mg twice daily] to 200mg per day[100mg twice daily]. This medicine is a film-coated tablet. Swallow it whole with water. It may be taken with or without food. If you miss a dose If you miss one or more doses, take one dose as soon as you remember, and then take the next dose at the next morning or evening dose time. When discontinuing treatment If you wish to stop taking this medicine, gradually reduce the dose by 50mg per day at 1-week intervals. After taking 50mg per day for 1 week, a dose of 20mg per day is recommended for the final week (see section ‘1. Warnings’). Elderly patients (65 years and older) Dose adjustment is not required for elderly patients. Clinical experience in elderly patients aged 65 years and older is limited. Renal impairment Dose adjustment is not required in patients with renal impairment. This medicine is not recommended for patients with end-stage renal disease who are receiving hemodialysis. Hepatic impairment Exposure to this medicine is increased in patients with hepatic impairment. The recommended initial dose for patients with hepatic impairment is 50mg per day[25mg twice daily], and the recommended maximum dose is 150mg per day[75mg twice daily].

This medication may cause serious mental health issues such as suicidal thoughts or behaviors, so care should be taken to monitor for these symptoms during treatment. This medication may lead to symptoms affecting the central nervous system, such as drowsiness, fatigue, dizziness, and coordination disturbances, so extra caution is advised when driving or operating machinery. If the medication is suddenly discontinued, seizures may occur more frequently; therefore, the dosage should be gradually reduced under medical supervision. Patients who are allergic to this drug or have specific inherited disorders such as lactose intolerance should not take it. Patients with poor liver function should have their dosage adjusted, so those with liver impairment should consult their doctor. Severe skin reactions like Stevens-Johnson syndrome, characterized by severe rashes or blisters, may occur; therefore, skin conditions should be closely monitored, and any abnormal symptoms should be reported to a healthcare professional immediately. This medication may interact with other antiepileptic drugs or certain medications, so inform your doctor or pharmacist if you are taking other drugs. Women who are pregnant or planning to become pregnant should consult with a healthcare professional before taking this medication, and caution is also needed for breastfeeding as the drug may be transferred to breast milk. Safety and efficacy have not been sufficiently verified in children under 16 years of age, so it is advisable not to use it in this age group. In case of overdose, symptoms such as drowsiness, dizziness, anxiety, and depression may occur; as there is no specific antidote, immediate medical treatment should be sought.

• suicidal thoughts
• suicidal behavior
• drowsiness
• fatigue
• dizziness
• psychomotor agitation
• influenza
• type 1 hypersensitivity reaction
• neutropenia
• decreased appetite

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is important to keep it at room temperature, specifically between 1 to 30 degrees Celsius, to maintain its effectiveness.

Appearance

Gray-green egg-shaped film-coated tablet

Package unit

PTP - 30 tablets/box [(10 tablets/PTP*3)]