Brivaracetam 100 mg (Brivaracetam)

Adult dose

This medicine is taken twice daily. The recommended initial dose is 25mg or 50mg per dose, based on the healthcare professional's assessment of potential adverse effects relative to seizure reduction. Based on clinical response and tolerability, the dose may be increased or decreased from 50mg per day [25mg per dose, twice daily] to 200mg per day [100mg per dose, twice daily]. Swallow this film-coated tablet whole with water. It may be taken with or without food. If you miss a dose If you miss one or more doses, take one dose as soon as you remember, and then take the next dose at the next scheduled morning or evening time. Discontinuation If you wish to stop taking this medicine, gradually reduce the dose by 50mg per day at 1-week intervals. After taking 50mg per day for 1 week, a dose of 20mg per day is recommended for the final week (see section 2. Warnings). Older adults (65 years and older) No dosage adjustment is required in older adults. Clinical experience in patients aged 65 years or older is limited. Renal impairment No dosage adjustment is required in patients with renal impairment. This medicine is not recommended for patients with end-stage renal impairment who are receiving hemodialysis. Hepatic impairment Exposure to this medicine is increased in patients with hepatic impairment. The recommended initial dose for patients with hepatic impairment is 50mg per day [25mg per dose, twice daily], and the recommended maximum dose is 150mg per day [75mg per dose, twice daily].

This medication may slightly increase the risk of suicidal thoughts or actions as it is an antiepileptic drug; therefore, both the patient and the caregiver should closely monitor for these symptoms during treatment. Side effects related to the central nervous system can occur such as drowsiness, fatigue, dizziness, and coordination disorders, especially at the beginning of treatment or when increasing the dosage. Abrupt discontinuation of this medication can lead to more frequent seizures, so it should be gradually reduced according to a doctor's instructions. Individuals allergic to this medication's active ingredient or other components should not take it, and it should not be given to those with lactose intolerance or certain genetic metabolic disorders. Patients with poor liver function need dosage adjustments while using this medication and should consult a physician. Should severe skin reactions such as rash, fever, or inflammation around the mouth or eyes appear during treatment, the medication should be stopped immediately, and medical advice should be sought. This medication can interact with other antiepileptic drugs, so if other medications are being taken, the doctor or pharmacist should be informed. Taking this medication with alcohol may further impair mental and motor function; thus, avoiding alcohol during treatment is advised. Women who are pregnant or planning to become pregnant should consult a doctor before taking this medication, and caution is necessary if breastfeeding, as the drug may be transmitted through breast milk. It is recommended not to use this medication in children under 16, as its safety and efficacy has not been adequately established for this age group. During treatment, symptoms such as drowsiness or dizziness may increase the risk of accidents while driving or operating machinery; hence, these activities should be avoided when such symptoms are present. In the case of overdose, since there is no specific antidote, one must visit a medical facility immediately for appropriate treatment, and blood dialysis is not significantly helpful in eliminating this medication. This medication should be stored in a safe place out of reach of children, and it is important not to transfer it to another container to maintain its quality.

• suicidal thoughts
• suicidal behavior
• drowsiness
• fatigue
• dizziness
• akathisia
• influenza
• Type I hypersensitivity reaction
• neutropenia
• decreased appetite

This medication should be stored in a tightly sealed container to prevent the entry of air or moisture. It is advisable to maintain a room temperature between 1 degree and 30 degrees Celsius.

Appearance

Oval film-coated tablet of greenish color

Package unit

30 tablets/bottle, 100 tablets/bottle