Nelson Acetaminophen Injection (Acetaminophen)

Adult administration

For adults weighing 50 kg and over, intravenous administration of acetaminophen 1000 mg should be done 4 times a day, with a dosing interval of at least 4 hours. The maximum daily dose must not exceed 4 grams. For adults weighing less than 50 kg, the intravenous administration of acetaminophen should be approximately 15 mg/kg (1.5 mL/kg) per administration, with a dosing interval of at least 4 hours. The maximum daily dose is 60 mg/kg or 4 grams.

Child administration

For children weighing 33 kg (approximately 11 years) or more, the intravenous injection of acetaminophen should be approximately 15 mg/kg (1.5 mL/kg) per administration, with a dosing interval of at least 4 hours. The maximum daily dose is 60.

This medication must be administered with precise dosage. Care must be taken due to potential serious poisoning or death from confusion between milligrams and milliliters. It is recommended to manage pain promptly with appropriate analgesics once oral administration is possible. Ensure that no other medications already contain acetaminophen to avoid overdose. Exceeding the recommended dosage of this medication can cause severe liver damage. Symptoms of liver damage may appear between 2 and 6 days after administration, and immediate treatment should be sought if problems are suspected. Patients with poor liver function or a history of liver disease should take this medication cautiously after consulting a doctor. Individuals who regularly consume alcohol are at increased risk of liver damage when taking this medication, and should consult a specialist. If symptoms like rash, hives, pustules, or severe skin reactions occur while taking this medication, stop taking it immediately and inform medical staff. Patients who are allergic to acetaminophen or this medication, or have peptic ulcers, severe blood disorders, liver impairment, kidney impairment, or heart failure should not use this medication. Patients with a history of aspirin-induced asthma or those taking certain medications should also avoid using this medication. Those with liver or kidney issues, bleeding tendencies, hypersensitivity, bronchial asthma, the elderly, children, pregnant women, and nursing mothers should use this medication with caution, and periodic examinations may be necessary. This medication may rarely cause various side effects such as liver function abnormalities, blood anomalies, neurological disturbances, skin rashes, and injection site reactions, so immediate consultation with medical personnel is necessary if any abnormal symptoms appear. It may interact with other medications, especially if taking probenecid, salicylamide, isoniazid, carbamazepine, phenobarbital, phenytoin, oral anticoagulants, or flucloxacillin, and these should be disclosed to a doctor or pharmacist. This medication does not affect driving or machinery operations, but should not be mixed with other drugs. Children and the elderly should take the minimum effective dose and closely monitor their condition if they have high fever or debilitating diseases after administration. The use of this medication during pregnancy is limited and must be considered cautiously in terms of benefits and risks, while it can generally be used safely in nursing mothers. Patients with severely impaired kidney function should increase the dosing interval, and in case of overdose, immediate hospital treatment for detoxification is required. Do not store this medication at temperatures above 30 degrees Celsius, avoid refrigeration or freezing, and check for foreign substances or discoloration before administration. Any unused solution should be discarded and used only once.

Serious side effects

Hypersensitivity reactions (including anaphylactic shock), shock, agranulocytosis, neutropenia, leukopenia, thrombocytopenia, coma, acute renal failure, similar to pustular reaction, pustular rash, Lyell's syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatitis, hepatic necrosis, liver failure, increased liver enzymes, angioedema, anaphylaxis, and hypersensitivity reactions requiring discontinuation of therapy (from rash/hives to anaphylaxis).

Mild side effects

• Fatigue
• hypotension
• increased liver transaminase levels
• neurological disorders
• maculopapular rash
• injection site reactions
• papular rash
• erythema
• flushing
• itching

This medication should be stored in a sealed container to prevent air and moisture from entering, and it is important to maintain a storage temperature between 1 and 30 degrees Celsius. Therefore, avoid very hot or very cold places for safe storage.

Appearance

A clear, light yellow, transparent liquid contained in a colorless, transparent plastic container for injection.

Package unit

100 milliliters/bag