Zepagin Duo Tablet 5/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is one tablet, twice daily. The dosage should be determined within the range not exceeding 25 mg of empagliflozin and 2000 mg of metformin for each patient's treatment regimen and tolerance. If blood sugar control is insufficient, empagliflozin 5 mg twice daily (total of 10 mg) can be combined with the existing dose of metformin. If tolerance is good and additional blood sugar control is needed, empagliflozin may be increased.

This medication is used in diabetes treatment with both components acting together to control blood sugar. When taking this medication, there is a risk of a rare side effect called severe lactic acidosis; if symptoms appear, consult a physician immediately. Additionally, caution is needed as there is a risk of hypoglycemia when taken with insulin or other diabetes medications. This medication should not be taken by patients with severely reduced kidney function or certain acute diseases. Before and after examinations that use iodine contrast agents, this medication should be temporarily discontinued and restarted only after confirming normal kidney function. In cases where surgery is scheduled, this medication should be stopped for a period before the procedure, but can be resumed after recovery. Patients with liver dysfunction, severe infections, dehydration, or poor nutritional status should use this medication with caution. It is safest for women who are pregnant or breastfeeding not to take this medication. Adverse effects such as gastrointestinal disturbances, infections, hypoglycemia, increased urination, abnormal liver function, and genitourinary infections may occur; these symptoms should be reported to a physician. Particularly, women need to pay attention to hygiene as genital infections may occur more frequently. It is advisable to regularly check kidney function and serum vitamin B12 levels when on this medication. Excessive alcohol consumption can increase the risk of adverse effects, so it should be avoided. This medication may interact with other drugs, so if other medications are being taken, please inform a physician or pharmacist. Elderly patients may have decreased kidney function, so dosage adjustments and regular monitoring are necessary. This medication is not recommended for children as safety and efficacy have not been established. In case of overdose, immediate medical attention should be sought, and dialysis may be required. This medication should be kept out of reach of children and stored in its original container.

Serious side effects

Hives, severe swelling (angioedema), ketoacidosis, lactic acidosis, necrotizing fasciitis, myocardial infarction, cerebral infarction, acute kidney injury, acute pyelonephritis, urosepsis, severe skin reactions (severe rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes), difficulty breathing, asthma attack, respiratory distress, liver abnormalities (jaundice), severe swelling (generalized edema), severe neurological symptoms (severe headache, seizures, confusion, visual disturbances).

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly closed container to protect it from air and moisture, and it is best kept at room temperature between 1 to 30 degrees Celsius. Storing it this way can help maintain the medication's effectiveness for a longer duration.

Appearance

Yellow-brown, oval, double convex film-coated tablet

Package unit

Bottle - 60 tablets/bottle, PTP - 60 tablets/box [(10 tablets/PTP x 6)]