Zepazinduo Tablet 5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet, twice daily. The dose is decided considering each patient’s current therapeutic regimen, efficacy, and tolerance within the maximum recommended daily limits of empagliflozin 25 mg and metformin 2000 mg. For patients not achieving adequate blood sugar control with monotherapy of metformin or in combination with other medications such as insulin, the recommended dose is 5 mg of empagliflozin twice daily (a total of 10 mg/day) along with the existing dose of metformin.

This medication is used to help control blood sugar in diabetes patients. When using this medication, caution is necessary as rare side effects such as severe lactic acidosis may occur. Lactic acidosis can lead to serious conditions due to excessive accumulation of lactic acid in the body, which can be life-threatening. Furthermore, caution is needed as there is a risk of hypoglycemia when used with other diabetes medications such as insulin or sulfonylureas. This medication should not be used in patients with moderate to severe renal dysfunction or in those with acute renal problems. In patients with severe heart failure or acute heart issues, severe infections, or dehydration, taking this medication may pose risks and should be avoided. When undergoing examinations using radiographic iodine contrast agents, this medication should be discontinued for a certain period before and after the exam, and it should only be resumed after confirming normal kidney function. Pregnant women, women who may become pregnant, and nursing mothers should avoid taking this medication. This medication can increase urination, potentially causing fluid loss or blood pressure drop, so special caution should be exercised in the elderly or those at risk of dehydration. While taking this medication, vitamin B12 levels may decrease, so it is advisable to check through blood tests if necessary. Alcohol consumption may worsen the effects of this medication on lactic acid metabolism, so excessive drinking should be avoided while taking this medication. This medication may cause hypoglycemic symptoms, so further caution is needed when meals are skipped or exercise levels are high, and in case of hypoglycemic symptoms, immediate consultation with medical personnel is essential. While taking this medication, genital or urinary tract infections may occur, so related symptoms should be reported immediately. If surgery is planned, this medication should be discontinued 48 hours prior to the surgery, and it should be resumed only after confirming the recovery of normal kidney function. Elderly patients are at higher risk for kidney function decline, so regular monitoring of kidney function is necessary, and dosage adjustments may be needed. In case of overdose, severe side effects may occur, so it is crucial to adhere to the prescribed dosage, and if unusual symptoms arise, immediate medical attention should be sought. Finally, this medication is not to be used in children, as its safety and efficacy in this population have not been established. Lastly, this medication should be stored out of reach of children and kept in its original container to maintain quality.

Serious side effects

Hives, angioedema, chest tightness, difficulty breathing, pallor, severe swelling, severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanying cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, decrease in urine output.

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is best to store the medication at room temperature between 1°C and 30°C. This way, the medication's effectiveness is maintained for a longer duration and can be used safely.

Appearance

White, oval, double-sided, convex film-coated tablet with a yellow tint

Package unit

Bottle - 60 tablets/bottle, PTP - 60 tablets/box [(10 tablets/PTP x 6)]