Empagliflozin/Metformin Hydrochloride Dual Tablet 12.5/1000 mg

Adult dose

The recommended dose of this medication is one tablet at a time, twice daily. Dosage should be adjusted based on each patient's therapy, efficacy, and tolerance within the maximum recommended daily doses of empagliflozin 25 mg and metformin 2000 mg. In cases where metformin is taken alone or in combination with other medications such as insulin, the recommended dose is empagliflozin 5 mg twice daily and the existing dose of metformin. If additional blood glucose control is needed while maintaining good tolerance, the dose of empagliflozin can be increased to 25 mg per day.

This medication is used for the treatment of diabetes and helps lower blood sugar levels. However, there are several precautions to take when using it. First, it can cause a rare side effect known as severe lactic acidosis. Lactic acidosis is a condition where there is an excessive accumulation of lactic acid in the body and can be life-threatening, requiring immediate medical attention if symptoms occur. Second, if taken alongside other diabetes medications such as insulin or sulfonylureas, there is a risk of hypoglycemia, so caution is necessary. Third, patients with moderate to severe renal impairment or those with specific conditions such as severe infections, dehydration, heart failure, or acute myocardial infarction should not take this medication. Fourth, if undergoing tests using iodinated contrast agents, this medication should be paused for a certain period before and after the test, and it should only be resumed after confirming normal kidney function. Fifth, it is safest for pregnant or breastfeeding women to refrain from taking this medication. Sixth, this medication can cause fluid loss, so elderly patients who are dehydrated or taking antihypertensive agents should take special care when using it. Seventh, gastrointestinal disturbances (nausea, vomiting, diarrhea, etc.), urinary infections, genital infections, and increased urination may occur, so if symptoms persist, consult a physician. Eighth, it is important to regularly monitor kidney function, blood glucose, and vitamin B12 levels while taking this medication. Ninth, in case of an overdose, there is a risk of lactic acidosis, thus immediate medical treatment is required. Lastly, this medication is not recommended for children, and dosage adjustments are necessary for the elderly based on kidney function. It is important to consult adequately with a physician or pharmacist before taking this medication and to inform healthcare personnel immediately if any unusual symptoms appear.

Serious side effects

• Severe lactic acidosis
• hypoglycemia (severe)
• ketoacidosis
• lactic acidosis
• urticaria
• angioedema
• perineal necrosis
• urosepsis
• pyelonephritis
• cerebral infarction

Mild side effects

• Hypoglycemia
• urinary infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

Store this medication in a tightly sealed container to protect it from air and moisture. It is preferable to keep the medication at room temperature between 1°C and 30°C. Avoid storing it in extremely hot or cold places, and keep it in a cool area away from direct sunlight.

Appearance

A biconvex oval film-coated tablet that is purple with a dark brown hue

Package unit

60 tablets/bottle, 60 tablets/box [10 tablets/PTP x 6]