Glyan Duo Tablet 12.5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet, taken twice daily. The dosage should not exceed the maximum recommended daily dosages of empagliflozin 25 mg and metformin 2000 mg. For patients who do not achieve sufficient blood sugar control with metformin alone or other medications such as insulin, it is recommended to take 5 mg of empagliflozin twice a day (totaling 10 mg) along with the existing dose of metformin. An increase to 25 mg of empagliflozin per day may be made if tolerance is good and additional blood sugar control is needed.

This medication helps to control blood sugar levels, but there are several precautions to consider when taking it. First, it can cause a rare side effect known as severe lactic acidosis. Lactic acidosis occurs when there is an excessive accumulation of lactic acid in the body, which can become dangerous, so if symptoms appear, one should seek immediate medical attention. Furthermore, when used in conjunction with other diabetes medications, the risk of hypoglycemia may occur, so it is important to carefully monitor blood sugar levels. This medication should not be used in patients with significantly impaired kidney function, acute infections, dehydration, heart problems, or liver dysfunction. Particularly, women who are pregnant or breastfeeding should avoid taking this medication for safety reasons. It should also be temporarily discontinued before and after surgeries or procedures involving radiologic contrast agents, and restarted only after confirming normal kidney function. This medication may increase the risk of urinary and genital infections, so if any infection symptoms appear, they should be treated promptly. During treatment, dehydration or hypotension may occur, so it is essential to closely monitor one's health and ensure adequate fluid intake. Additionally, vitamin B12 levels may decrease, so regular blood tests are recommended for long-term use. Alcohol consumption can increase the risk of lactic acidosis, so drinking is to be avoided while on this medication. Elderly patients or those with weakened kidney function should exercise particular caution and require regular monitoring of kidney function. In the event of an overdose, serious side effects such as hypoglycemia or lactic acidosis may occur, so dosage must be strictly adhered to. Finally, this medication should be stored out of the reach of children and kept in its original container for safety. Patients should adhere to the precautions mentioned above while taking this medication and consult healthcare professionals immediately if any abnormal symptoms occur.

Serious side effects

• Urticaria
• severe swelling (edema)
• angioedema
• perineal necrosis
• severe rash with fever
• blisters
• skin peeling
• pain in mucous membranes of mouth/eyes
• shortness of breath
• asthma attacks

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to prevent exposure to air or humidity, ideally at room temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be maintained for a longer period.

Appearance

Pinkish white, biconvex oval film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP × 5)]