Jardiance Duo Extended-Release Tablet 25/1000 mg (Empagliflozin, Metformin)

Adult dose

The 10/1000 mg or 25/1000 mg extended-release tablet of this medication is taken once daily, 1 tablet at dinner with meals. The dose of metformin hydrochloride should be increased gradually, and to maintain its extended-release characteristics, the tablet should not be split, crushed, ground, or chewed, but swallowed whole. The initial recommended dose is 10 mg of empagliflozin along with the patient's current dose of metformin, and if well tolerated, empagliflozin can be increased.

This medication is used to treat type 2 diabetes and helps lower blood sugar levels. However, it can rarely cause a serious condition known as lactic acidosis, so caution is warranted. Additionally, hypoglycemia may occur when used in conjunction with insulin or other diabetes medications. This medication should not be used in patients with significantly impaired kidney function or acute kidney problems. Patients with unstable cardiac function or acute heart failure should also refrain from using this medication. It is important to temporarily discontinue this medication before and after tests that use iodine-based contrast agents, and to resume only after confirming normal kidney function. Pregnant women or those with placental function issues should avoid using this medication. This medication can lead to fluid volume loss, so it should be used with caution in cases of dehydration, severe diarrhea, or vomiting. Patients with liver impairment should also avoid this medication, and excessive alcohol consumption is risky. Regular monitoring of kidney function and serum vitamin B12 levels is recommended during treatment. This medication may increase the risk of genital infections and urinary tract infections, so if any related symptoms arise, medical consultation should be sought immediately. Furthermore, hypoglycemic symptoms can occur, so caution should be exercised, especially after skipping meals or following exercise. This medication should be discontinued at least 48 hours prior to surgery, and resumed only after kidney function has recovered post-surgery. This medication should be swallowed whole without crushing, chewing, or breaking, and it is normal for the tablet shell to be excreted. Elderly patients or those with impaired kidney function may require dose adjustments and regular monitoring. In case of overdose, there is a risk of lactic acidosis, and prompt medical treatment should be sought. It is important to avoid acute or chronic alcohol consumption during treatment. Lastly, keep this medication out of reach of children and store it in its original container.

Serious side effects

Urticaria, angioedema, perineal necrosis, lactic acidosis, diabetic ketoacidosis, urosepsis, pyelonephritis, acute kidney injury, liver abnormalities (hepatitis, abnormal liver function tests), severe allergic reactions, severe skin reactions, significant neurological symptoms (cerebral infarction, headache, confusion, paralysis, etc.), severe edema, hypoglycemia (including severe hypoglycemia), severe respiratory difficulties (difficulty breathing, asthma attacks), heart failure exacerbation, acute cholecystitis

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly closed container to protect it from air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink rectangular extended-release film-coated tablet

Package unit

30 tablets/bottle