Hyaluronic Acid One-Stop Injection (BDDE Cross-linked Sodium Hyaluronate Gel) (Pre-filled)

Adult dosage

1 dose, 1 syringe injected into the knee joint, but the administration interval should be considered based on symptoms (at least 6 months).

This medication should not be used in patients with an allergy to this medication or its components. It should not be administered in cases of infection or severe inflammation at the injection site. It is also not to be used if there is skin infection or skin disease at the injection site. Patients with a history of allergic reactions to other medications should use this medication with caution. Patients with liver dysfunction or a history of liver disorders should be careful as well. During the administration of this medication, severe allergic reactions such as shock may occur, so symptoms should be closely monitored. If any abnormal signs occur, administration should be stopped immediately and appropriate treatment should be received. Common reactions at the injection site include pain, redness, swelling, and warmth, but most will resolve naturally over time. For joints with severe inflammation, it is advisable to reduce inflammation before administering this medication. Intense exercise or activities that strain the joint should be avoided for 48 hours after administration, and measures to stabilize the joint are desirable. This medication must be injected accurately into the joint, as it can cause pain if it leaks outside the joint. Administration should be performed by experienced medical personnel under aseptic conditions. The safety and efficacy of using this medication in conjunction with other intra-articular injectable drugs have not been confirmed, so it should not be combined. Pregnant or breastfeeding women are not recommended to use this medication as its safety has not been established. It is also not recommended for children as its safety and efficacy have not been established. Elderly patients may have diminished physiological function, so caution is necessary during administration; however, it is generally known that there is not a large difference in drug response between elderly and younger populations. This medication should be administered into the knee joint under aseptic technique, and if there is a large amount of joint fluid, it should be aspirated before administration. It should not be administered intravascularly, outside the joint, or into lubricating tissues. During administration, the enclosed syringe needle must be used, and care should be taken as it may react with disinfectants and cause precipitation. This medication is for single use and should not be reused or re-sterilized. If the packaging or syringe is damaged, it should not be used. The injection site should be thoroughly disinfected with alcohol or similar agents before administration, and any remaining medication and used syringes should be disposed of safely. When administering to both knees, different needles should be used for each. If symptoms do not improve, it is advisable not to re-administer the medication. Store out of reach of children and keep in the original container to maintain the quality of the medication.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in oral or ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme drowsiness throughout the body, sudden and severe headache, thunderclap headache, seizures, consciousness disturbances, visual abnormalities, paralysis, urination.

Mild side effects

• Pain
• erythema
• swelling
• warmth
• nasopharyngitis
• fever
• upper respiratory tract infection
• limb pain
• cystitis
• dyspepsia

This medication should be stored in a container that can block light and is best kept at room temperature between 1°C and 30°C. Additionally, care should be taken to ensure that the container is sealed tightly to prevent air and moisture ingress when using the medication.

Appearance

A colorless, transparent, and viscous gel contained in a colorless transparent glass or plastic tube (pre-filled syringe) sealed with rubber caps at both ends.

Package unit

(3.0mL/ Pre-filled Syringe) x 1