Empagliflozin/Metformin Sustained-Release Tablets 10/1000 mg

Adult dose

The dosage of this medication should be determined considering each patient's current treatment regimen, effectiveness, and tolerance without exceeding the maximum daily doses of 25 mg of empagliflozin and 2000 mg of sustained-release metformin hydrochloride. This medication should be taken once daily with the evening meal to reduce gastrointestinal side effects caused by metformin. The recommended starting dosage is 10 mg of empagliflozin and metformin.

This medication is used for the treatment of diabetes and helps in controlling blood sugar. When taking this medication, there is a risk of a rare side effect known as severe lactic acidosis, so symptoms must be closely monitored. Lactic acidosis is a condition where there is an excessive buildup of lactic acid in the body, which can be very dangerous. Additionally, caution is required when taken with insulin or sulfonylurea medications due to the risk of hypoglycemia. Patients with impaired kidney function, acute kidney problems, serious infections, congestive heart failure, acute myocardial infarction, or other specific health conditions should not take this medication. The use of iodine contrast agents before and after examinations requires temporary cessation of this medication, and it should be restarted only after kidney function has been confirmed as normal. Women who are pregnant or might become pregnant, patients with liver dysfunction, and patients who are in very poor nutritional status are also advised not to use this medication. During treatment, side effects such as hypoglycemia, urinary tract infections, genitourinary infections, increased urination, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, constipation, reduced and deficient vitamin B12 levels, taste disturbances, itching, rashes, abnormal liver function tests, hepatitis, urinary difficulties, interstitial nephritis, thirst, increased serum lipids, increased blood creatinine/decreased glomerular filtration rate, increased hematocrit, weight loss, lumbar pain, headaches, dizziness, insomnia, nausea, and gastritis may occur, so symptoms should be closely monitored. Especially for elderly patients aged 75 and older, there is an increased risk of fluid loss, so careful administration is required. This medication should be swallowed whole without breaking or chewing, and the tablet shell may pass in the stool, which is normal. Additionally, alcohol consumption may increase the risk of lactic acidosis, so alcohol should be avoided during treatment. Regular monitoring of kidney function and serum vitamin B12 levels during the use of this medication is recommended. If any abnormal symptoms or discomfort occur, consultation with a physician should be sought immediately, and prompt treatment is necessary in case of emergency.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions
• Severe rash with high fever, blisters, skin peeling, pain in the mouth/eye mucosa, severe skin reactions
• Shortness of breath or difficulty breathing, asthma attacks, abnormal breathing accompanied by cough and fever
• Yellowing of skin or eyes (jaundice), extreme fatigue, liver abnormalities (jaundice)
• Sudden and severe headache

Mild side effects

Hypoglycemia, urinary tract infection, genitourinary infection, increased urination, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, constipation, decreased and deficient vitamin B12 levels, taste disturbances, itching, rashes, abnormal liver function tests, hepatitis, urinary difficulties, interstitial nephritis, thirst, increased serum lipids, increased blood creatinine/decreased glomerular filtration rate, increased hematocrit, weight loss, lumbar pain, headaches, dizziness, insomnia, nausea, gastritis

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pale pink, bilaterally convex, oval-shaped sustained-release film-coated tablet

Package unit

30 tablets per bottle