Iris Stop Tablet 5 Micrograms (Ramosetron Hydrochloride)

Adult dose

For males, ramosetron hydrochloride is administered orally at 5 micrograms once daily. The dosage should be adjusted appropriately based on symptoms, with a minimum daily dose of 2.5 micrograms and a maximum daily dose of 10 micrograms. For females, ramosetron hydrochloride is administered orally at 2.5 micrograms once daily. If symptom relief is insufficient, the dose may be increased; however, the maximum daily dose is 5 micrograms.

This medication should not be used in individuals with known hypersensitivity to any of its components. Caution should be taken when using in patients receiving other serotonergic drugs, for example, selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Constipation or hardened stools may often occur as side effects while taking this medication, so caution is warranted. If symptoms like abdominal pain or bloody stools indicative of ischemic colitis appear, discontinue use immediately and consult a doctor. Severe and persistent constipation may lead to serious complications such as intestinal obstruction, so consult a healthcare professional upon experiencing symptoms of constipation. Severe allergic reactions such as shock or anaphylaxis may occur during the use of this drug, so immediate treatment is necessary if unusual symptoms appear. Pregnant women or women of childbearing potential should only use this medication when the benefits outweigh the risks, and it is recommended to discontinue breastfeeding if nursing. Safety during use in children or infants has not been established, thus its use is not recommended. Elderly patients may have reduced physiological functions, so their condition should be closely monitored when using this medication, and use should be discontinued immediately if adverse reactions occur. When taking this medication, ensure to remove the tablet from the blister pack and avoid swallowing the pack itself. Since this medication is metabolized in the liver, caution is needed when taken with drugs that may affect liver function due to the potential increase in blood concentration. Caution should also be exercised when used in combination with medications that may cause constipation, such as anticholinergics or anti-diarrheal agents, as it may worsen constipation. This medication can be taken independently of meals, but frequent dosage adjustments based on changes in symptoms should be avoided. Prior attempts should be made to control diet and improve lifestyle as the basic treatment for irritable bowel syndrome, and it is advisable to use this medication only when symptoms do not improve.

Serious side effects

• Hives
• severe swelling (edema)
• shock
• anaphylaxis
• respiratory distress
• chest tightness
• ischemic colitis
• severe constipation
• intestinal obstruction
• bowel occlusion

Mild side effects

• Constipation
• hardened stools
• nausea
• vomiting
• abdominal pain
• upper abdominal pain
• gastric discomfort
• gastritis
• abdominal discomfort
• hemorrhoids

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to maintain storage temperature between 1 to 30 degrees Celsius. Avoid storage in extremely hot or cold places.

Appearance

Pale yellow round film-coated tablets

Package unit

100 tablets/box [(10 tablets x 10 PTP)], 10 tablets/box [(10 tablets x 1 PTP)]