Hyushiglome Sustained Release Tablet 5/50/1000 mg (Dapagliflozin, Sitagliptin, Metformin)

Adult dose

The recommended dosage of this medication is 10 mg of dapagliflozin and 100 mg of sitagliptin, with sustained-release metformin hydrochloride being determined within a range that does not exceed 2000 mg based on each patient's current therapy, efficacy, and tolerability. This medication should be taken once daily preferably in the evening with meals, and the dosage of metformin hydrochloride should be adjusted gradually if needed. 10/100/1000 mg.

This medication contains a mixture of ingredients used in the treatment of diabetes. First, the sitagliptin component may rarely cause serious allergic reactions. Such reactions can occur within three months of starting the medication, so if symptoms like skin rash or difficulty breathing develop, it is essential to stop taking the medication immediately and consult a doctor. Moreover, sitagliptin poses a risk of acute inflammation of the pancreas (acute pancreatitis), so if abdominal pain, nausea, or vomiting occur during treatment, medical personnel must be informed immediately. The metformin ingredient may rarely lead to a severe metabolic disorder known as lactic acidosis. This condition can cause symptoms such as vomiting, abdominal pain, muscle pain, difficulty breathing, and lethargy, and immediate medical attention should be sought if it occurs. This medication is not to be administered to patients with moderate to severe renal impairment, dehydration, severe infection, heart failure, acute myocardial infarction, or other kidney or heart-related issues. Moreover, this medication must be discontinued before examinations involving radiological iodinated contrast agents, and it can only be resumed after confirming normal kidney function post-examination. Patients who are pregnant or who have severely impaired liver function should also not use this medication. During treatment with this medication, side effects such as hypoglycemia, fluid loss, urinary and genital infections may occur; if symptoms arise, immediate consultation with a physician is necessary. In particular, patients with reduced fluid volume or low blood pressure, elderly individuals, and those with decreased kidney function should take extra caution and undergo regular kidney function tests. This medication can induce a severe metabolic complication known as diabetic ketoacidosis, so if symptoms of ketoacidosis appear even when blood sugar levels are not elevated, immediate treatment should be sought. Finally, alcohol consumption should be avoided while taking this medication, and if symptoms of dehydration or severe gastrointestinal disturbances occur, the medication should be discontinued and a doctor consulted.

Serious side effects

• Rash
• severe swelling (edema)
• tightness in the chest
• difficulty breathing
• cold sweat
• pallor
• anaphylaxis
• angioedema
• Stevens-Johnson syndrome
• exfoliative skin disease

Mild side effects

Headache, upper respiratory tract infection, nasopharyngitis, diarrhea, nausea, constipation, dry mouth, back pain, muscle pain, limb pain, fatigue, weakness, fever, itching, rash, cold sweat, dermatitis, dry skin, weight loss, urinary tract infection, dysuria, nocturia, hypoglycemia, fluid loss (including dehydration, hypovolemia), dyspepsia, nausea, vomiting, abdominal pain, reduced appetite, sensory abnormalities, drowsiness, muscle cramps, muscle weakness, joint pain, abnormal sweating, blood levels.

Store this medication in a tightly sealed container to prevent exposure to air or moisture. It is recommended to keep the storage temperature between 1 and 30 degrees Celsius.

Appearance

Pale yellow, bilaterally convex, oval sustained-release film-coated tablet

Package unit

30 tablets/bottle