EmpaAnduo Extended Release Tablet 25/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be determined considering each patient's current treatment, efficacy, and tolerability, without exceeding the recommended maximum daily doses of 25 mg of empagliflozin and 2000 mg of extended-release metformin hydrochloride. This medication should be taken once daily in the evening with food. To maintain its extended-release characteristics, this medication should be swallowed whole and not split, crushed, or chewed. This medication comes in a 25/1000 mg formulation.

This medication is a diabetes treatment combining two components, empagliflozin and metformin hydrochloride. Caution is required as a rare side effect of severe lactic acidosis may occur while taking this medication. Lactic acidosis is a condition where lactic acid builds up excessively in the body, which can be life-threatening in severe cases. Additionally, there is a risk of hypoglycemia when taken with insulin or sulfonylurea medications, so caution is needed. Patients with moderate to severe renal impairment, acute kidney issues, severe infections, heart failure, or acute myocardial infarction should not take this medication. In particular, the intake of this medication should be discontinued before and after examinations using iodinated contrast agents, and should be resumed only after renal function has been confirmed to be normal. This medication may cause gastrointestinal disorders (such as diarrhea, vomiting) and there is a possibility of urinary tract infections or genital infections. Therefore, if infection symptoms occur, it is necessary to consult a healthcare professional immediately. Patients at risk of reduced fluid volume should be cautious of dehydration or low blood pressure, and elderly patients or those with declining renal function should undergo regular kidney function tests. It is recommended that women who are pregnant, potentially pregnant, or nursing do not take this medication. While taking this medication, alcohol consumption should be avoided, and irregular meals, intense physical activity, or the use of other hypoglycemic agents can increase the risk of hypoglycemia, so caution is advised. This medication should be swallowed whole without crushing, chewing, or splitting it, and the tablet shell may sometimes appear in the stool, which is normal. In case of overdose, there is a risk of lactic acidosis, and immediate medical treatment is required. Blood dialysis may be performed if necessary. Finally, when storing this medication, keep it out of reach of children, and store it in its original container for safety.

Serious side effects

• Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions
• Severe rash accompanied by high fever, blisters, peeling skin, pain in the mucous membranes of the mouth/eyes, severe skin adverse reactions
• Shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever
• Yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice)
• Sudden and severe headache

Mild side effects

Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, constipation, altered taste, itching, rash, erythema, hypoglycemia, decreased vitamin B12, increased serum creatinine, increased hematocrit, thirst, increased urination, difficulty urinating, dyspepsia, weakness, weight loss, headache, dizziness, insomnia, fatigue, facial swelling, chest pain, fever, immune system infections (vaginal candidiasis, vulvovaginitis, balanitis, soft tissue infection, pneumonia, upper respiratory infection)

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to maintain the storage temperature between 1 to 30 degrees Celsius.

Appearance

Pale green oval extended-release film-coated tablets

Package unit

30 tablets/bottle