Domenxia Tablets 10/20 mg (Donepezil Hydrochloride Hydrate, Memantine Hydrochloride)

Adult dose

For patients receiving combined dosing of donepezil hydrochloride 10 mg and memantine hydrochloride 20 mg, take one tablet daily at the same time before bedtime. It can be taken regardless of food intake.

This medication should not be used in certain patients. For example, it should not be administered to patients who are allergic to this drug or its components, patients with severe liver or kidney dysfunction, women who are pregnant or breastfeeding, and patients with genetic issues such as lactose intolerance. In addition, patients with epilepsy or a history of seizures, those using specific NMDA antagonists concurrently, patients with heart disease or uncontrolled hypertension, patients with a history of peptic ulcers, asthma or chronic obstructive pulmonary disease patients, and patients with extrapyramidal disorders such as Parkinson's disease should use this medication with caution. This drug may cause various side effects, including cardiac arrhythmias, gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, movement disorders, severe muscle disorders, respiratory distress, acute pancreatitis, acute renal failure, and sudden death. Commonly, symptoms such as nausea, vomiting, diarrhea, dizziness, insomnia, headache, fatigue, loss of appetite, hallucinations, and aggressive behavior may occur. Due to potential side effects related to heart rhythm, patients with a history of heart disease should be particularly cautious, and an electrocardiogram may be necessary. Women who are pregnant or breastfeeding are advised not to use this medication; even when necessary, careful consultation with a professional is recommended. This medication is not used in children and adolescents under 18, as its safety and efficacy have not been established. In the case of overdose, symptoms such as nausea, vomiting, bradycardia, respiratory depression, confusion, drowsiness, aggression, and seizures may occur, and immediate medical attention is required. This medication may affect the ability to drive or operate machinery; therefore, caution should be exercised while taking it. Finally, this medication should be kept out of the reach of children, and transferring it to another container may compromise its quality.

Serious side effects

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal ulcer
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Headache
• dizziness
• drowsiness
• nausea
• vomiting
• diarrhea
• loss of appetite
• fatigue
• muscle pain
• rash

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Yellowish oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle