Kwangdong L-Arginine Hydrochloride Injection

Adult administration

Administer L-Arginine Hydrochloride at a dosage of 0.2 to 1g per kg of body weight through slow intravenous drip over at least one hour.

This drug should not be used in patients who frequently experience allergic reactions or have a history of hypersensitivity to any component of this medication. Moreover, it should not be administered to patients in severe acidosis, patients with low blood pressure, patients with diseases related to nitric oxide production, those with a history of myocardial infarction, and patients with arginine-degrading enzyme deficiencies. Caution is required when using this drug in patients with severe liver impairment, severely impaired kidney function, uremia, electrolyte imbalances, or those with bronchial asthma. Rapid administration of this drug may result in symptoms such as nausea, vomiting, skin redness, headache, numbness, and vein irritation. Rarely, hypotension, anaphylactic reactions, severe allergic reactions, or hyperkalemia may occur, so attention is necessary. If allergic symptoms occur during administration, antihistamines should be used, and blood pressure should be continuously monitored for 24 hours during and after administration. If hyperammonemia does not improve, additional treatments such as dialysis or exchange transfusions may be necessary. Excessive dosing of hydrochloride components may lead to increased chloride concentration in the blood, resulting in acidosis, thus monitoring the acid-base status of the blood should be done regularly. This drug may interact with spironolactone, so caution should be taken when used together. Women who are pregnant or may become pregnant should use this medication cautiously only when necessary, and breastfeeding mothers should ideally avoid administration or stop breastfeeding while using it. In case of overdose, metabolic acidosis and hyperventilation may occur, and persistent acidosis needs to be corrected with alkalizing agents. If signs of redness, swelling, skin necrosis or ulcers are suspected around the injection site when administering intravenously, administration should be stopped immediately, and appropriate treatment should be sought. Do not use if the solution is discolored, cloudy, has precipitates, exceeds its expiration date, or if the packaging is damaged. Store this medication out of the reach of children, and unused portions of the solution should not be reused.

Serious side effects

• Possible hypotension
• anaphylactic reactions
• severe allergic reactions
• severe hyperkalemia
• skin necrosis
• ulcers
• urticaria
• and severe swelling (edema).

Mild side effects

• Nausea
• vomiting
• erythema
• headache
• numbness
• partial vein irritation
• hyperammonemia
• skin ulcers
• increased blood urea
• hypersensitivity

This medication should be stored in a sealed container to prevent contact with air, and it should be kept at a temperature between 1 degree and 30 degrees Celsius at room temperature. Storing it in this manner helps maintain the drug's efficacy and safety.

Appearance

A colorless, transparent solution filled in a polypropylene, multi-layer film plastic container for injection.

Package unit

100 milliliters/pack