Medication info

Difen Col Cold Syrup

OTC medicationSyrup경구
Ingredient · strength
Acetaminophen›325mg / 20mLChlorpheniramine Maleate›2.5mg / 20mLDextromethorphan Hydrobromide Hydrate›16mg / 20mLDL-Methylephedrine Hydrochloride›21mg / 20mLGuaifenesin›83mg / 20mLAnhydrous Caffeine›25mg / 20mL
Manufacturer / importer
동성제약(주)
Appearance
A red aromatic sweet syrup contained in an aluminum foil pouch.
Packaging
5 pouches/box [(20 mL/pouch X 5ea)]
Approval status
Active

MFDS item code 202402092 · Notified 2024.08.29

Summary

Main use
Relief of cold symptoms (runny nose, stuffy nose, etc.)
Who takes it
Adults · Children
Adult dose
For ages 15 and above, take 1 packet (20 mL) three times a day after meals, 30 minutes after. Generally, the dosing interval is 4 hours.
Child dose
For ages 11 to under 15 years, take 2/3 packet three times a day after meals, 30 minutes after. For ages 7 to under 11 years, take 1/2 packet three times a day after meals, 30 minutes after. For ages 3 and above,

Ingredients

Manufacturer
동성제약(주)

Efficacy & effects

Relief of cold symptoms (runny nose, stuffy nose, etc.)

  • Runny nose
  • nasal congestion
  • sneezing
  • sore throat
  • cough
  • phlegm
  • chills
  • fever
  • headache
  • joint pain
  • muscle pain
View approved original text

This medication is used to alleviate various symptoms of a cold, including runny nose, nasal congestion, sneezing, sore throat, cough, phlegm, chills, fever, headache, joint pain, and muscle pain.

How to take

Adult dose

For ages 15 and above, take 1 packet (20 mL) three times a day after meals, 30 minutes after. Generally, the dosing interval is 4 hours.

Child dose

For ages 11 to under 15 years, take 2/3 packet three times a day after meals, 30 minutes after. For ages 7 to under 11 years, take 1/2 packet three times a day after meals, 30 minutes after. For ages 3 and above,

Precautions

This medication can put stress on the liver, so individuals who regularly consume more than three drinks of alcohol a day should consult a doctor or pharmacist before taking it. Additionally, very rarely, serious skin reactions can occur due to the ingredients in this medication, so if a rash or allergic symptoms develop, the medication should be stopped immediately. The maximum daily dose of acetaminophen in this medication is 4,000mg, so care should be taken not to exceed this dosage or take it with other acetaminophen-containing medications. Individuals with a history of hypersensitivity reactions, those who have experienced asthma, infants under 3 months old, or people taking certain antidepressants or antipsychotic medications should not take this medication. During treatment, care should be taken not to combine this medication with cough and phlegm medications, other cold medications, antipyretics, sedatives, or antihistamines. Especially children, the elderly, pregnant and nursing women, and individuals with liver, kidney, or heart diseases should consult a healthcare professional before taking this medication. If symptoms like rash, itching, vomiting, dizziness, insomnia, or shortness of breath occur after taking this medication, it should be stopped immediately and a doctor should be consulted. This medication should not be used in children under 2 years of age, and if necessary, a doctor's consultation is required. It is important to adhere to the prescribed dosage and duration of use, avoid long-term use, and avoid alcohol while taking the medication as it may cause drowsiness; thus, driving or operating machinery is not advisable. Finally, when taking this medication with certain antibiotics or other drugs, caution is required due to the possibility of side effects. This medication should be stored in a cool, dry place out of the reach of children and should not be transferred to another container.

Side effects and when to seek care immediately

Serious side effects

  • Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reactions
  • Severe rash with high fever, blisters, peeling skin, mucosal pain in the mouth/eyes → severe skin adverse reactions
  • Asthma
  • Liver dysfunction: general malaise, jaundice → liver problems (jaundice)
  • Coughing, shortness of breath, fever → respiratory issues

Mild side effects

  • Rash
  • redness
  • itching
  • nausea
  • vomiting
  • loss of appetite
  • constipation
  • swelling
  • difficulty urinating
  • thirst
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  • dizziness
  • anxiety
  • tremors
  • insomnia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. This will help preserve the medication's effectiveness and safety.

Appearance and packaging

Appearance

A red aromatic sweet syrup contained in an aluminum foil pouch.

Package unit

5 pouches/box [(20 mL/pouch X 5ea)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.