Hwanin Memantin Orally Disintegrating Tablet 20 mg (Memantine Hydrochloride)

Adult dose

This medication is taken orally once daily, at the same time each day. If necessary, it can be administered twice daily. Place the orally disintegrating tablet on the tongue and let it dissolve without taking it with water. The dosage increase is up to a maximum daily dose of 20 mg, and the dose should be increased by 5 mg weekly over the first 3 weeks. First week (Days 1-7): 5 mg once daily Second week (Days 8-14): 10 mg once daily Third week (Days 15-21): 15 mg once daily Fourth week and onward: 20 mg once daily.

This medication contains the artificial sweetener aspartame, which breaks down into phenylalanine in the body. Therefore, patients with the hereditary condition phenylketonuria should not take this medication. The daily intake of aspartame should be adjusted to not exceed 40 mg per kg of body weight, and for adults, a maximum of 2.4 g per day is considered safe. Patients who are hypersensitive to this medication, those with severe liver disease, and those with significantly diminished kidney function should not take this medication. Patients with epilepsy or a history of seizures should use this medication cautiously, and co-administration with certain NMDA antagonists should be avoided due to increased risk of side effects. Additionally, caution is advised in situations where urine acidity may change, in patients with recent myocardial infarction, heart failure, or uncontrolled hypertension. Side effects may include dizziness, headache, constipation, drowsiness, and hypertension, and psychiatric symptoms or seizures may occur in some patients. There may be interactions with other medications, so consultation with a doctor or pharmacist is required, especially when taking NMDA antagonists, antipsychotics, skeletal muscle relaxants, or anticoagulants. Women who are pregnant or may become pregnant should make a careful decision about taking this medication, as it may pose risks to the fetus, and breastfeeding women are advised to discontinue breastfeeding while using this medication. Safety and efficacy have not been established in children and adolescents under 18 years old, so it is advisable not to use it in this population. In case of overdose, severe symptoms such as coma, hallucinations, and seizures may occur, requiring immediate medical treatment, and since there is no specific antidote, symptomatic treatment is necessary. Finally, this medication may affect a patient's reaction time and concentration, so caution should be exercised while driving or operating machinery, and it should be stored out of reach of children and not transferred to other containers.

Serious side effects

• Seizures
• vascular disorders
• severe allergic reactions
• severe skin reactions
• respiratory problems
• liver abnormalities (jaundice)
• severe neurological symptoms
• severe edema
• or urinary abnormalities

Mild side effects

• Dizziness
• headache
• constipation
• drowsiness
• hypertension
• fungal infection
• drug hypersensitivity reaction
• confusion
• hallucinations
• psychiatric reactions

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, avoid extremely hot or cold places, and store at room temperature between 1 and 30 degrees Celsius.

Appearance

White round orally disintegrating tablet

Package unit

90 tablets/box [(10 tablets/PTP × 9)]