Zyprexa Tablet 2.5 mg (Olanzapine)

Adult dose

The therapeutic dose of this medicine should be adjusted according to the patient's clinical condition. Increases above the usual recommended daily dose of 10 mg are recommended only after appropriate clinical evaluation. Adults Schizophrenia: The recommended initial dose is 5∼10 mg of olanzapine once daily. Maintenance treatment of schizophrenia: Although it is difficult to give a definitive answer regarding how long treatment with this medicine should continue, efficacy was demonstrated in a placebo-controlled study in which patients with schizophrenia whose symptoms had stabilized after taking this medicine for approximately 8 weeks received maintenance treatment for 8 months at doses of 10∼20 mg daily. The need for maintenance treatment at an appropriate dose should be assessed periodically. Treatment of manic and mixed episodes associated with bipolar I disorder: The initial dose is 15 mg of this medicine once daily as monotherapy, or 10 mg once daily as adjunctive therapy with lithium or valproate. Prevention of recurrence in bipolar disorder: The recommended initial dose is 10 mg once daily. Patients who have been receiving this medicine to treat mania should continue the same dose to prevent recurrence. If a new manic, mixed, or depressive episode occurs, treatment with this medicine should continue, with adjunctive therapy to treat mood symptoms as clinically indicated (optimizing the dose as needed). Treatment of schizophrenia and manic and mixed episodes associated with bipolar I disorder, and prevention of recurrence in bipolar disorder: The daily dose may be adjusted within the range of 5 mg to 20 mg once daily based on clinical status. Increases above the recommended initial dose are advised only after appropriate clinical evaluation, and the dose should generally be increased at intervals of at least 24 hours. If treatment with this medicine is discontinued, the dose should be reduced gradually and cautiously. Acute treatment of depressive episodes associated with bipolar I disorder: Start treatment with olanzapine 5mg once daily, then increase to 10mg once daily. Administer this medicine at bedtime and adjust the dose as appropriate according to age and symptoms; the daily dose should not exceed 20mg. Since food does not affect drug absorption, this medicine may be taken with or without food. Elderly patients: Starting at a dose of 5 mg or less daily may be considered when supported by sufficient clinical factors. Patients with renal or hepatic impairment: A low initial dose (5 mg) should be considered. In moderate hepatic impairment (cirrhosis, Child-Pugh class A or B), the initial dose is 5 mg and should be increased cautiously. Patients with a combination of factors that delay the metabolism of this medicine (female sex, older age, and nonsmoking status) may also be started at a low dose.

This medication is an antipsychotic and can cause serious side effects such as neuroleptic malignant syndrome, which can be life-threatening. It is not approved for the treatment of psychosis or behavioral disorders associated with dementia, and the mortality rate and the risk of cerebrovascular events may increase in elderly patients receiving this medication. Long-term use may result in movement disorders such as tardive dyskinesia, and if symptoms appear, consideration should be given to dose adjustment or discontinuation. Monitoring of patients is essential as it may take time for clinical conditions to improve. Patients with diabetes or risk factors should regularly monitor their blood sugar and weight, as this medication can affect blood sugar control. Sudden discontinuation may cause symptoms such as insomnia, anxiety, and nausea, so gradual tapering is important. Caution is necessary for patients with certain heart conditions, elderly patients, and patients with liver dysfunction, and attention must be paid to drug interactions. Pregnant or breastfeeding women should consult a physician before use, as it may affect the fetus or newborn. This medication can cause drowsiness and dizziness, so caution is required when driving or operating hazardous machinery. Serious side effects may occur with overdose, and the prescribed dosage must be strictly adhered to, keeping the medication out of reach of children.

• High fever
• muscle rigidity
• changes in mental status
• irregular pulse
• blood pressure changes
• tachycardia
• sweating
• cardiac arrhythmia
• elevated creatine phosphokinase
• myoglobinuria

This medication should be stored in a tightly closed container to prevent air or moisture from entering, preferably at room temperature between 15 and 30 degrees Celsius. This storage method helps maintain the efficacy of the medication for a long time.

Appearance

Film-coated white round tablet

Package unit

28 tablets (7 tablets/PTPX4)/carton