Trinames Tablet 2.5/1000 mg (Linagliptin, Metformin)

Adult dose

This medication should be taken with food once daily, preferably with the evening meal. The dosage of metformin hydrochloride should be increased gradually, and it should be swallowed whole without splitting, crushing, or chewing. The 5/1000 mg prolonged-release tablet is taken once daily at a single dose of 1 tablet. The 2.5/1000 mg prolonged-release tablet is taken once daily at a single dose of 2 tablets simultaneously. 1. If not currently treated with metformin.

This medication can rarely cause serious lactic acidosis or hypoglycemia, requiring caution. It should not be administered to patients allergic to its components, nor to those with type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. Patients with severely impaired kidney function or conditions that may lead to acute changes in kidney function should also avoid this medication. Patients with severely impaired cardiac or pulmonary function, liver dysfunction, acute alcohol intoxication, or alcoholic disease should avoid using this drug. This medication should not be used in pregnant women or those with placental dysfunction or preeclampsia. Caution is advised when using this drug alongside other blood sugar lowering agents due to an increased risk of hypoglycemia, which may require dosage adjustments of other medications. Lactic acidosis is very rare but can be fatal; if symptoms such as vomiting, diarrhea, muscle cramps, abdominal pain, or weakness occur, immediate medical attention is required. Regular kidney function checks are essential, particularly for elderly or renally impaired patients. Patients with acute heart failure or heart disease should use this drug cautiously and must stop it temporarily before and after undergoing tests with radiopaque iodine contrast agents. Patients scheduled for surgery should discontinue this medication 48 hours prior to the procedure and resume it only after normal kidney function has returned post-surgery. Acute pancreatitis or bullous skin disorders such as dermatitis herpetiformis may occur while on this medication; if such symptoms arise, inform your doctor immediately. Tablets must be swallowed whole and not crushed or chewed; it is normal for the tablet coating to be excreted in feces. Long-term use may lower vitamin B12 levels, hence regular checks of vitamin B12 should be conducted. This medication may interact with various drugs, so patients should inform their doctor or pharmacist about any other medications they are taking. It is recommended to avoid this medication during pregnancy or breastfeeding, especially since its components may transfer into breast milk. Safety and efficacy in children have not been established. Elderly patients may have reduced kidney function, necessitating careful dosage adjustments and regular kidney function assessments. Overdosing may result in lactic acidosis or other serious symptoms, requiring immediate medical treatment. Store this medication out of reach of children, avoid moisture, and do not transfer it into other containers.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• dermatitis herpetiformis
• angioedema
• liver enzyme abnormalities
• hepatitis
• angina
• acute myocardial infarction

Mild side effects

• Hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcer

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is important to keep it at room temperature between 1°C and 30°C to maintain its efficacy.

Appearance

White oval prolonged-release film-coated tablet with IH 2.5/1000 engraved on one side

Package unit

28 tablets (7 tablets/PTP×4)/box, 30 tablets/bottle, 100 tablets/bottle