Lidipom Extended Release Tablet 5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

The 5/1000 mg extended release tablet is taken once daily, with one tablet per dose. For patients taking the 2.5/1000 mg extended release tablet, two tablets should be taken simultaneously once daily. 1. If not currently being treated with Metformin: The initial dose of this medication is a total daily amount of 5 mg linagliptin and 1000 mg metformin hydrochloride, and the metformin hydrochloride may be gradually increased to the maximum recommended daily dose of 2000.

This medication may cause a rare side effect called lactic acidosis, therefore caution is required. It should not be administered to patients with severely impaired renal function or those in a state of severe infection or dehydration. Patients with allergies to this medication or those with type 1 diabetes or diabetic ketoacidosis should also avoid use. Patients with severely impaired cardiac function or liver dysfunction should also refrain from using this medication. It should not be used during pregnancy or in cases of acute alcohol intoxication. This medication carries a risk of hypoglycemia; thus, when used with insulin or sulfonylureas, blood glucose must be closely monitored. Symptoms of lactic acidosis include difficulty breathing, weakness, and abdominal pain, and if such symptoms occur, the doctor must be notified immediately. Renal function is crucial, and regular kidney function tests should be performed before and during treatment, and the medication should be discontinued if renal function declines. If iodinated contrast is used for radiological tests, this medication should be suspended for a certain period before and after the tests, and renal function should also be re-evaluated. Patients scheduled for surgery should discontinue this medication 48 hours prior to surgery and resume it once renal function is normal after the surgery. While taking this medication, rare side effects such as acute pancreatitis or skin vesicles resembling bullous pemphigoid may occur, so any symptoms should be reported immediately. This medication should be swallowed whole without crushing or chewing, and it is normal for the tablet coating to pass out in stool. Long-term use may lead to vitamin B12 deficiency, so regular blood tests may be required. This medication may interact with several other medications; therefore, if other medications are being taken, one must consult a physician or pharmacist. Elderly patients are commonly prone to impaired renal function, therefore dosing adjustments and monitoring of kidney function are particularly important. It is not recommended for use during pregnancy or breastfeeding without consulting healthcare professionals. Overdose may result in serious side effects such as lactic acidosis, necessitating immediate hospital treatment. This medication should be stored out of reach of children and kept away from moisture, avoiding transfer to other containers.

Serious side effects

Hives, angioedema, lactic acidosis, severe allergic reactions, angioedema, severe swelling (edema), difficulty breathing, severe skin adverse reactions (fever with severe rash, blisters, skin peeling, mucosal pain in mouth/eyes), severe swelling or urination abnormalities (significant reduction in urine output, severe systemic edema, accompanied by increased blood pressure), acute pancreatitis, sudden and severe headaches, seizures, confusion, vision abnormalities, paralysis

Mild side effects

Nasopharyngitis, immune system abnormalities (excluding hypersensitivity), taste disorders, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, abnormal liver function tests, hepatitis, itching, erythema, rashes, severe and non-disabling arthralgia, increased serum lipase, increased amylase, abnormal vitamin B12 absorption test, hypoglycemia (when combined with sulfonylureas), increased serum creatinine, dizziness, headache, drowsiness

This medication may be sensitive to air or moisture, and should therefore be stored in a sealed container. Additionally, for safe use of the medication, it is best to store it at room temperature between 1°C and 30°C.

Appearance

Oval extended release tablet, white to almost white, engraved with L5M on one side

Package unit

28 tablets/box [7 tablets/PTP x 4], 30 tablets/bottle