Myungmoon Linagliptin Duo Extended-Release Tablets 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication should be taken once a day with meals, preferably with the evening meal. The 5/1000 mg extended-release tablet is taken once daily, 1 tablet at a time. Patients taking the 2.5/1000 mg extended-release tablet should take 2 tablets at once, once daily. If not currently treated with metformin, the initial total daily dose is 5 mg of linagliptin and 1000 mg of metformin hydrochloride.

This medication consists of two main ingredients that mainly assist with blood sugar control. However, there is a risk of rare but serious lactic acidosis, so caution is necessary. This medication should not be used in certain patients. For example, it should not be administered to individuals with an allergy to this medication or any of its components, those with type 1 diabetes, severe kidney dysfunction, severe liver dysfunction, acute infection, or acute myocardial infarction. Additionally, patients who are acutely or chronically alcohol intoxicated, those in very poor nutritional states, patients with acute and unstable heart failure, and pregnant women who may pose a risk to the fetus should avoid this medication. When administering this medication, it is important to pay attention to symptoms of hypoglycemia. The risk of hypoglycemia may increase, especially when taken with insulin or sulfonylureas, so blood sugar levels should be monitored frequently and doses adjusted as necessary. Lactic acidosis is very rare but can be fatal, so if symptoms such as sudden abdominal pain, muscle weakness, breathing difficulties, or lethargy appear, immediate consultation with medical personnel is necessary. Patients with decreased kidney function may have difficulty excreting this medication, increasing the risk of side effects, so renal function tests should be conducted regularly before and during treatment, and this medication should not be used if kidney function falls below a certain level. Patients with poor cardiac function or heart failure should also use this medication with caution, and cardiac status should be monitored regularly. When intravenous iodinated contrast agents used in radiological examinations are administered, they may affect kidney function and increase the risk of side effects from this medication, so it is advisable to discontinue this medication for a certain period before and after the examination. In cases of surgery, this medication should be discontinued 48 hours prior to surgery and should only be resumed after renal function has recovered post-surgery. During treatment with this medication, acute pancreatitis or vesicular skin diseases may occur, so if persistent severe abdominal pain or skin abnormalities arise, notify a doctor immediately. The metformin component can interfere with vitamin B12 absorption, thus regular testing for vitamin B12 deficiency during long-term use is advisable. This medication should not be crushed or chewed but should be swallowed whole, and it is normal for the tablet coating to be excreted in feces. Due to potential drug interactions, especially with medications that affect kidney function or blood sugar control, patients should inform medical personnel and take precautionary measures. Use of this medication is not recommended during pregnancy or while breastfeeding, and if planning to become pregnant, appropriate treatment options should be discussed with a healthcare professional. For the safety of children, this medication should be stored out of reach of children and in a dry place. In case of overdose, serious side effects such as lactic acidosis may occur, necessitating immediate medical treatment.

Serious side effects

• Hives
• angioedema
• lactic acidosis
• pancreatitis
• erythema multiforme
• chest tightness
• difficulty breathing
• respiratory distress
• asthma attacks
• peeling skin

Mild side effects

• Hypoglycemia
• taste disturbances
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers

This medication should be stored in a tightly closed container to protect it from air and moisture, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

Oval extended-release tablet, white to nearly white with '25LM' engraved on one side

Package unit

28 tablets/box (7 tablets/PTP x 4)