Rinacombi Sustained Release Tablet 5/1000 mg (Linagliptin, Metformin)

Adult dose

Take this medication once a day with the evening meal. For the 5/1000 mg sustained-release tablet, take 1 tablet once daily. For the 2.5/1000 mg sustained-release tablet, take 2 tablets together once daily. If not currently being treated with metformin, the initial dosage is linagliptin 5 mg and metformin hydrochloride 1000 mg, with a maximum gradual increase up to 2000 mg. Met

This medication assists in blood sugar control, and one of its active ingredients, metformin, can rarely cause a dangerous condition called lactic acidosis. Lactic acidosis occurs when there is an excessive buildup of lactic acid in the body, and if not treated immediately, it can be life-threatening. This medication should not be used in certain patients. For instance, it should not be given to those who are allergic to this medication or its components, patients with type 1 diabetes, patients with severe kidney dysfunction, patients with acute infections or serious trauma, patients with liver dysfunction, patients suffering from acute alcohol intoxication, patients with severely poor nutritional status, or pregnant women. This medication may cause hypoglycemia, and caution should be exercised, especially when used in conjunction with other hypoglycemic agents or insulin. Additionally, if lactic acidosis is suspected, this medication should be stopped immediately and medical attention sought. Before treatment initiation and during treatment, kidney function should be regularly monitored; if kidney function is impaired, this medication should not be used. Patients with poor heart function should also use this medication with caution. When taking this medication, use of iodinated contrast media for radiological tests or surgeries should involve a temporary discontinuation prior, and the medication should be resumed only after normal kidney function is confirmed. Adverse reactions such as acute pancreatitis or vesicular skin disorders may occur during treatment, and if persistent abdominal pain or skin vesicles develop, the patient should inform their doctor immediately. Side effects of this medication may include gastrointestinal symptoms (abdominal pain, diarrhea, nausea, vomiting, etc.), hypoglycemia, skin rash, liver dysfunction, muscle pain, etc., and vitamin B12 deficiency may occur, so regular monitoring is required with prolonged use. This medication should be swallowed whole and not chewed or crushed, although the tablet coating may appear in the feces, which is normal. When taken with other medications, interactions may occur, thus careful management in accordance with a doctors instructions is necessary, especially with drugs affecting kidney function or hypoglycemic agents. It is generally advisable not to use this medication during pregnancy or breastfeeding, and its safety and efficacy in children have not been established. Elderly patients may have decreased kidney function, so dosage adjustments and regular monitoring of kidney function are required. In the event of an overdose, steps should be taken to ensure the drug is not fully absorbed from the gastrointestinal tract, and if necessary, treatment may involve dialysis to remove the drug. This medication should be stored out of reach of children, in a moisture-free environment, and not transferred to another container.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, pemphigoid, chest tightness, difficulty breathing, asthma attacks, yellowing of the skin or eyes (jaundice), sudden and severe headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output, severe swelling of the body with increased blood pressure, angioedema, severe allergic reactions, severe swelling or urinary changes, cardiac disorders (acute myocardial infarction, cardiac arrest)

Mild side effects

• Dysgeusia
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcer
• abnormal liver function

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. The recommended storage temperature is between 1 and 30 degrees Celsius.

Appearance

White, oval, sustained-release film-coated tablet imprinted with AI 5/1000 on one side

Package unit

28 tablets (7 tablets/PTPX4) / box, 30 tablets / bottle, 100 tablets / bottle