Samigolrin Tablet 30 mg (Nisergoline)

Adult dose

Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, it may be increased to 60 mg. The dose may be reduced after symptoms improve. Reduce the dose in patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL).

This drug should not be administered to certain patients. For example, it is contraindicated in patients who are allergic to this drug or ergot alkaloids, patients with acute myocardial infarction or acute hemorrhage, patients taking sympathomimetic drugs, patients with very low heart rate, patients who have not completed hemostasis after cranial hemorrhage, and patients with orthostatic dysregulation. Also, it should be administered cautiously to patients with mild bradycardia or impaired kidney function. Rarely, gastrointestinal symptoms such as dyspepsia, diarrhea, constipation, nausea, vomiting, abdominal pain, and dry mouth may occur when using this drug. Liver function test results may increase, and rare cardiovascular abnormalities such as dizziness, orthostatic hypotension, blood pressure changes, and increased serum uric acid levels may also occur. Neurological symptoms such as drowsiness, fatigue, headache, tinnitus, and insomnia may also appear. Additionally, hypersensitivity reactions such as rashes, urticaria, itching, flushing, and heat sensation may occur. Blood pressure should be checked frequently during the use of this medication, especially since the blood pressure may lower further when taken with antihypertensive agents. It can affect uric acid metabolism, so caution is advised for patients with gout or hyperuricemia. After taking the medication, caution should be exercised when driving or operating machinery. This drug is metabolized in the liver, so interactions with other medications may occur. Women who are pregnant or may become pregnant should be cautious when using this drug, and it is advisable to avoid taking it while breastfeeding or to discontinue breastfeeding. Elderly patients may require dose adjustments due to decreased body functions. Safety in children has not been confirmed, so caution should be exercised in their use. In case of overdose, blood pressure may temporarily drop, so blood pressure changes should be observed closely and necessary measures should be taken. This medication should be stored out of the reach of children and kept sealed in its original container to maintain its quality and prevent misuse.

Loss of appetite, diarrhea, constipation, nausea, vomiting, spontaneous upper abdominal pain or cramping, thirst, elevated ALT, elevated AST, dizziness, postural hypotension, hypertension, elevated blood uric acid, hypotension, drowsiness, fatigue, headache, tinnitus, tiredness, insomnia, rash, urticaria, itching, flushing, heat sensation, nightmares, mood disturbances, indigestion

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it should be kept away from extremely hot or cold places, ideally in a temperature range of 1 to 30 degrees Celsius.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle