Cition Tablets 30mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally 2 ∼ 3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, it may be increased to 60 mg. The dose may be reduced after symptoms improve. Reduce the dose in patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL).

This medication should not be used in certain patients. For instance, individuals who are allergic to this medication or to ergot alkaloids should not take it. Additionally, patients with acute myocardial infarction or acute bleeding, patients on sympathomimetic agents, patients with very slow heart rates (bradycardia), those who have not completed hemostasis after intracranial bleeding, and patients with orthostatic dysregulation should also refrain from taking this medication for safety. Patients with mild bradycardia or kidney function issues should use this medication with special caution. Rarely, gastrointestinal symptoms such as decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain or cramps, and dry mouth may occur after taking this medication. There may also be rare instances of elevated liver function test results. Symptoms of cardiovascular abnormalities such as dizziness, orthostatic hypotension, hypertension, increased blood uric acid levels, and decreased blood pressure have also been reported rarely. Neuropsychiatric symptoms may include drowsiness, fatigue, headache, tinnitus, tiredness, and insomnia. Moreover, allergic reactions such as skin rash, urticaria, itching, flushing, and hot flashes may occur rarely. While taking this medication alongside antihypertensive agents, blood pressure should be closely monitored to prevent excessive hypotension. Caution is warranted in patients with a history of hyperuricemia or gout as this medication may affect uric acid metabolism. Care must be taken when driving or operating machinery after administration. This medication is metabolized by certain enzymes (CYP450 2D6) in the liver, so drug interactions may occur if taken with other medications that utilize the same enzyme. Pregnant women or women who may become pregnant should only take this medication if the benefits of treatment outweigh the risks, as its safety has not been established. Breastfeeding women should avoid taking this medication if possible, or should discontinue breastfeeding due to the possibility of the medication being excreted in breast milk. Elderly individuals, whose bodily functions may be diminished, should use this medication with adjustments in dosing as necessary. The safety of this medication has not been adequately established in children. In cases of overdose, blood pressure may temporarily lower, so blood pressure changes should be monitored, and necessary measures should be taken. This medication should be stored out of reach of children and kept in its original container with the lid tightly closed.

Loss of appetite, diarrhea, constipation, nausea, vomiting, generalized upper abdominal pain or cramps, thirst, elevated ALT, elevated AST, dizziness, orthostatic hypotension, hypertension, increased blood uric acid, blood pressure reduction, drowsiness, fatigue, headache, tinnitus, tiredness, insomnia, rash, hives, itching, flushing, feeling of warmth, nightmares, mood disturbances, indigestion

This medication should be stored in a sealed container that blocks light, at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain its effectiveness and prevent deterioration.

Appearance

Yellow round film-coated tablets

Package unit

100 tablets/bottle, 30 tablets/bottle