Linagliptin Plus XR Tablets 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

Take this drug once daily with dinner. For the extended-release property, do not break, crush, grind, or chew; swallow whole. For 5/1000 mg extended-release tablets, take 1 tablet once daily. For 2.5/1000 mg extended-release tablets, take 2 tablets simultaneously once daily. The initial dose is 5 mg of Linagliptin and 1000 mg of Metformin Hydrochloride.

This drug contains Metformin Hydrochloride and Linagliptin as its main components and is an antidiabetic medication that helps regulate blood sugar levels. This drug can rarely cause a metabolic complication known as lactic acidosis, so patients at risk of lactic acidosis should avoid its use. In particular, patients with severely impaired kidney function, type 1 diabetes, or those with acute myocardial infarction or severe infections should not use this drug. This drug may cause hypoglycemia; therefore, blood glucose levels should be carefully monitored when used together with other antidiabetic medications such as insulin or sulfonylureas. It is important to regularly check kidney function during treatment to assess renal status. Rare side effects such as acute pancreatitis or vesicular skin disorders may occur, so if severe abdominal pain or skin abnormalities arise during treatment, advice should be sought from a physician immediately. Prolonged use may lead to vitamin B12 deficiency, so if anemia or neurological symptoms occur, vitamin B12 levels should be checked. This drug should be swallowed whole without crushing, chewing, or breaking it, and the tablet shell may appear in feces, which is normal. Alcohol consumption may increase the risk of lactic acidosis, hence it is advisable to avoid it. Prior to and after tests using iodinated contrast agents, this drug should be temporarily discontinued, and kidney function should be verified. Elderly patients may have a higher risk of declining kidney function, so dose adjustments and monitoring of kidney function are necessary. Women who are pregnant or planning to become pregnant should avoid using this drug, and it is also recommended that breastfeeding women do not use it. When administering this drug with others, the possibility of drug interactions should be considered and discussed with a physician. In cases of overdose, severe side effects such as lactic acidosis may occur, necessitating immediate medical attention.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, similar dermatitis, severe allergic reactions, severe skin reactions, severe edema, cardiac disorders (angina, acute myocardial infarction, unstable angina, cardiac arrest), dyspnea, asthma, acute kidney injury, acute renal failure, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute pyelonephritis, sepsis, acute myocardial infarction, congestive heart failure, sudden and severe headache, confusion of consciousness, vision

Mild side effects

• Pharyngitis
• hypersensitivity
• hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This drug is sensitive to air and moisture, and should be stored in a tightly sealed container. It is also advisable to store it at room temperature, between 1 to 30 degrees Celsius, avoiding extreme heat or cold.

Appearance

Yellow ovate extended-release film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle