Flogam Duo Extended-Release Tablets 10/500 mg (Dapagliflozin, Metformin)

Adult dose

The dosage of this medication should be individualized based on the patient's current treatment, efficacy, and tolerance, without exceeding the maximum recommended dose of dapagliflozin 10 mg and extended-release metformin 2000 mg. Generally, it is administered once daily with the evening meal. The maximum dosage is dapagliflozin 10 mg/extended-release metformin 2000 mg once daily, given as 2 tablets of 5 mg/1000 mg. For those without prior experience of diabetes medication,

This medication may rarely cause a serious condition called lactic acidosis, so patients with reduced kidney function or problems with heart, liver, or lung function should be especially cautious. This medication can cause hypoglycemia when used in combination with other diabetes medications, so dosage adjustments may be necessary when used concurrently with insulin or sulfonylureas. Patients with moderate or severe renal impairment, dehydration, serious infections, or cardiovascular issues should not take this medication. If undergoing imaging tests using iodinated contrast agents, this medication should be discontinued 48 hours before the test and resumed only after kidney function is confirmed to be normal. Pregnant or potentially pregnant women and nursing mothers should not use this medication, and its safety and efficacy in children have not been established. This medication can cause depletion of fluid volume and low blood pressure, so elderly patients or those on diuretics or with low blood pressure should be cautious while taking it. There may be an increased risk of genital and urinary tract infections during use, so any related symptoms should be reported to healthcare professionals immediately. Vitamin B12 levels may decrease, so patients taking it long-term should have regular blood tests to monitor this. Excessive alcohol consumption may heighten the risk of side effects with this medication; therefore, it is advisable to avoid alcohol while taking it. Patients scheduled for surgery should discontinue this medication 48 hours before the procedure and can resume it after kidney function has been restored post-surgery. During treatment, dizziness or symptoms of hypoglycemia may occur, requiring caution while driving or operating machinery. Store this medication away from the reach of children and keep it in its original container to maintain quality.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• acute renal failure
• renal impairment
• diabetic ketoacidosis
• urosepsis
• pyelonephritis
• acute kidney injury
• worsening renal function
• necrotizing fasciitis

Mild side effects

• Vulvovaginitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• dry mouth
• dizziness
• constipation
• back pain
• dysuria

This medication must be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain storage temperatures between 1 degree and 30 degrees Celsius. Proper storage will help preserve the medication's effectiveness.

Appearance

Pink oval extended-release film-coated tablets

Package unit

28 tablets/box [7 tablets/PTP x 4]