Cephazolin 0.5 Gram Injection (Cephazolin Sodium)

Adult administration

For infections caused by gram-positive bacteria, 1 to 2 g (potency) should be administered as a divided intravenous injection 2 to 3 times a day. For infections caused by gram-negative bacteria, 3 to 4 g (potency) should be administered in divided doses 2 to 3 times a day. For life-threatening infections and infections caused by moderate susceptibility bacteria, the dose may be increased up to 6 g (potency) per day. When administering intravenously, dissolve 1 g (potency) of this medication in 5 mL of sterile water for injection and administer it slowly over 2 to 3 minutes.

This drug should not be used by individuals allergic to cephalosporin antibiotics or in preterm infants and neonates. Caution is advised when administering to pregnant women in early pregnancy or patients with kidney or liver dysfunction, those with hemophilia or thrombocytopenia, and patients with gastrointestinal ulcers. Patients who have difficulty with oral intake or are receiving parenteral nutrition, as well as elderly patients or those in poor general condition, may show symptoms of vitamin K deficiency, so they should be carefully monitored. Mild reactions such as headache, dizziness, and nausea may occur when using this medication, and rarely, skin rashes, fever, or severe allergic reactions may appear. If any abnormal symptoms occur, use should be discontinued immediately and medical attention should be sought. Liver function test results may increase, or there may be a temporary decrease in white blood cell count. If abdominal pain, diarrhea, or bloody stools occur, the medication should be stopped, and treatment should be initiated. Symptoms such as difficulty in breathing, cough, and fever may indicate lung inflammation, so immediate medical attention should be sought. Oral infections such as stomatitis or candidiasis may occur, and symptoms of vitamin K and B deficiency should also be monitored closely. To prevent the occurrence of resistant bacteria, it is important to conduct susceptibility tests and use the drug for only the minimum necessary duration. Adequate history taking and skin reaction tests are recommended before administration to reduce the risk of allergic reactions or shock. Patients should be carefully monitored in a stable condition after administration. When used with other antibiotics, caution is needed as it may stress the kidneys, and diligence is required when combining with drugs that can affect blood coagulation. When breastfeeding, use should be done with caution as a small amount of the drug may be transmitted through breast milk. Lastly, this drug should not be mixed with other antibiotics in the syringe for use.

Serious side effects

Severe allergic reactions (anaphylaxis), respiratory problems (dyspnea, cough accompanied by fever), severe skin reactions (severe rash, blisters, skin peeling, pain in mucous membranes of mouth/eyes), severe edema or urination abnormalities (generalized severe edema)

Mild side effects

Transient mild headache, dizziness, nausea, rash, fever, anaphylaxis, increases in AL-P, GOT, GPT, transient leukopenia, pseudomembranous colitis, bloody stools, abdominal pain, frequent diarrhea, vomiting, loss of appetite, fever, cough, dyspnea, abnormal chest X-ray findings, eosinophilia, stomatitis, candidiasis, vitamin K deficiency symptoms (hypoprothrombinemia, bleeding tendency), vitamin B deficiency symptoms (glossitis, stomatitis, loss of appetite)

This drug should be stored in a sealed container to prevent air and moisture from entering, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness.

Appearance

A white to yellowish powder in a colorless and transparent vial.

Package unit

10 vials/box [(0.5 grams/vial) X 10]