Niron Tablets 30 mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally 3 times daily before meals. The dose may be adjusted appropriately according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, it may be increased to 60 mg. The dose may be reduced after symptoms improve. For patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

This medication should not be administered to certain patients. For instance, individuals allergic to this medication or ergot alkaloids should not take it. Moreover, it may be hazardous for patients with acute myocardial infarction or acute bleeding. Patients on sympathomimetic agents or those with very slow heart rates should also avoid this medication. Patients who have not completed hemostasis after intracranial hemorrhage and those with orthostatic regulation disorders should refrain from using this medication. Mild bradycardia patients or those with kidney function issues should use this medication cautiously. When taking this medication, gastrointestinal symptoms such as loss of appetite, diarrhea, constipation, nausea, and vomiting may rarely occur. Liver function test values may rise, so caution should be taken regarding liver health. Symptoms such as dizziness, changes in blood pressure, fatigue, headache, and drowsiness may also rarely arise. Allergic reactions such as rash, urticaria, itching, or facial flushing can occur, and if any abnormal symptoms arise, immediate consultation with a doctor is recommended. This medication has a blood pressure-lowering effect; therefore, when taken with antihypertensive drugs, blood pressure may drop too low, so frequent monitoring is necessary. It may affect uric acid levels, so caution is required for patients with gout or hyperuricemia. After administration, drowsiness or decreased concentration may occur, so care should be taken when driving or operating machinery. This medication is metabolized in the liver through specific enzymes (CYP450 2D6), so there may be interactions with other medications that use this metabolic pathway. Women who are pregnant or may become pregnant should use this medication cautiously, as its safety has not been established, and it has been reported to potentially harm the fetus in animal studies during pregnancy. Nursing mothers should ideally avoid taking this medication, and if necessary, should discontinue breastfeeding. Elderly patients may have reduced physiological function, thus requiring careful dose adjustment. Safety for pediatric use has not been established, so it is not recommended for children. If this medication is overdosed, temporary low blood pressure may occur, thus blood pressure changes must be monitored closely and appropriate measures should be taken if needed. This medication should be stored out of reach of children, and it is important to keep it sealed in its original container. Transferring it to another container may deteriorate quality and pose a risk of accidents.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• episodic upper abdominal pain or cramps
• thirst
• ALT increase
• AST increase
• dizziness

This medication is sensitive to light and should be stored in a tightly sealed container that does not allow light in. It is important to maintain a storage temperature between 1 and 30 degrees Celsius room temperature. Proper storage will help maintain the effectiveness and safety of the medication.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 60 tablets/bottle