Nesinamet Tablet 12.5/1000 mg (Alogliptin Benzoate, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be adjusted based on efficacy and tolerability, without exceeding the recommended maximum daily dosage of 25 mg of alogliptin and 2000 mg of metformin. The initial dosage of this medication should be determined according to the patient's current treatment regimen. This medication should be taken twice daily with meals to reduce gastrointestinal side effects associated with metformin, and the dose increase should be gradual.

This medication contains metformin hydrochloride and alogliptin benzoate as the main components and is used to control blood sugar levels. Care should be taken when taking this medication as severe lactic acidosis or hypoglycemia may occur. Lactic acidosis is a rare but potentially fatal metabolic complication that can be more likely to occur during sudden kidney function decline, cardiopulmonary diseases, or infections. This medication should not be administered to certain patients. For example, it should not be taken by individuals who are hypersensitive to alogliptin or metformin, or those with severe kidney impairment, heart failure, acute myocardial infarction, or sepsis. Additionally, the use of radiocontrast iodine tests can affect kidney function, so this medication should be temporarily discontinued before and after the tests, and should only be resumed after kidney function is confirmed to be normal. Caution is also required for pregnant or breastfeeding women, patients with severe liver dysfunction, severe infections, and pre- or post-surgical patients when taking this medication. This medication may cause side effects such as gastrointestinal disturbances, headaches, infections, and hypoglycemia, and especially hypoglycemia symptoms should be closely monitored. The risk of hypoglycemia is higher during irregular meals, excessive exercise, or when combined with other hypoglycemic agents. Symptoms of lactic acidosis include fatigue, muscle pain, difficulty in breathing, and abdominal pain, so these symptoms should prompt immediate consultation with a physician. Regular liver and kidney function checks should be conducted, and caution should be heightened particularly for the elderly or patients with impaired renal function. Furthermore, alcohol consumption can increase the risk of lactic acidosis, so it is advisable to avoid drinking alcohol. There may be interactions with other medications while taking this medication, so if other medications are being taken, it is essential to inform the doctor or pharmacist. Rare side effects such as bullous pemphigoid or severe arthralgia may occur, so if there are any skin abnormalities or severe joint pain, immediate notification to the medical staff is necessary. Finally, the safety and efficacy of this medication in pediatric patients have not been established, so it should not be used in children.

Serious side effects

Hives, severe swelling (edema), chest tightness, shortness of breath, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, difficulty breathing, asthma attacks, respiratory issues accompanied by cough + fever, yellowing of the skin or eyes (jaundice), severe lethargy, sudden and severe headache, lightning pain, seizures, confusion, visual disturbances, paralysis, urination.

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• diarrhea
• hypertension
• headache
• back pain
• urinary tract infections
• hypoglycemia
• nausea/vomiting
• bloating

This medication should be stored in a tightly sealed container to prevent air or moisture ingress. Additionally, the medication should be kept away from areas that are too hot or too cold, preferably stored at room temperature between 1 and 30 degrees Celsius.

Appearance

Pale yellow oblong film-coated tablet

Package unit

Blister - 28 tablets/Alu-Alu[(7 X 4)], Bottle - 30 tablets/bottle[(bottle-HDPE, cap-PP, silica gel)], Bottle - 100 tablets/bottle[(bottle-HDPE, cap-PP, silica gel)]