Duglow 10/15 mg Tablets (Dapagliflozin Propanediol Hydrate, Pioglitazone Hydrochloride)

Adult dose

This medication is administered once daily, 1 tablet at a time, regardless of meals. The recommended starting dose is 10 mg of dapagliflozin and 15 mg of pioglitazone once daily. The dosage may be increased to 10/30 mg once daily based on tolerability and blood sugar control response. For patients with an estimated glomerular filtration rate (eGFR) of 45 mL/min/1.73 m2 or higher, dosage adjustments are not necessary. For patients with an eGFR below 45 mL/min/1.73 m2, this medication should not be administered.

This medication should not be used in patients with heart failure or a history of heart failure. Symptoms and signs of heart failure should be closely monitored when starting treatment or increasing the dosage, as heart failure may worsen. If heart failure symptoms occur, it is important to inform a healthcare professional immediately for appropriate treatment, which may include stopping or reducing the dosage of this medication. This medication should not be administered to patients with active bladder cancer or a history of bladder cancer. If new or worsening symptoms such as hematuria or urinary disturbances occur, inform a doctor immediately to rule out the possibility of bladder cancer. Patients with severely impaired liver function should not use this medication. Those with liver dysfunction must undergo liver function tests before treatment and periodically monitor for liver-related symptoms or test results during therapy. This medication is not suitable for patients with severely impaired kidney function, particularly those undergoing dialysis. In patients with moderate to severe renal impairment, the effectiveness of blood sugar control may be reduced, and the decision to administer should be made cautiously based on renal function. Patients with type 1 diabetes, diabetic ketoacidosis, diabetic coma, those undergoing surgery, or patients with severe infections or serious trauma are not suitable for this medication. In such cases, insulin treatment is recommended. Women who are pregnant or may become pregnant should not take this medication, and patients with certain genetic disorders such as hereditary lactase deficiency should also avoid this medication. This medication can cause fluid volume reduction and hypotension, so elderly patients or those with renal impairment or on diuretics should thoroughly evaluate their fluid status and blood pressure before administration, and periodically monitor symptoms and kidney function during therapy. While this medication lowers blood sugar, the risk of hypoglycemia can increase, especially when combined with other diabetes medications such as insulin or sulfonylureas. Therefore, symptoms of hypoglycemia should be closely monitored, and prompt action should be taken if symptoms occur. During the use of this medication, infections, especially genital and urinary infections, can occur, so prompt treatment is necessary if infection symptoms develop. Rarely, side effects such as skin rash, allergic reactions, liver function abnormalities, edema, weight gain, dizziness, headache, abdominal distension, dyspepsia, diarrhea, vomiting, urinary retention, weakness, chest pain, fatigue, pain, and peripheral edema may occur. If unusual symptoms persist or worsen, consult with a healthcare professional. During therapy, regular blood tests and physical examinations are essential to monitor liver function, kidney function, blood sugar levels, etc., and appropriate measures should be taken if any anomalies are detected.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, seizure, confusion, visual disturbances, paralysis, significantly decreased urine output

Mild side effects

• Nausea
• generalized edema
• soft tissue infections
• weight gain
• exercise-induced dyspnea
• drowsiness
• facial edema
• peripheral edema
• thirst
• constipation

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

White to off-white, biconvex, round tablets

Package unit

Bottle - 30 tablets/bottle