Nesinamet Sustained Release Tablet 25/1000 mg (Alogliptin, Metformin Hydrochloride)

Adult dose

Take one tablet of this 25/1000 mg sustained release medication once daily. Patients taking the 12.5/1000 mg or 12.5/500 mg sustained release tablets should take two tablets concurrently once daily. 1. If you are not currently being treated with metformin: - The initial dosage is a total daily amount of alogliptin 25 mg and metformin hydrochloride 1000 mg. - If the initial dosage does not adequately control blood sugar...

This medication can cause severe lactic acidosis or hypoglycemia; therefore, it should not be used, especially in patients with poor kidney function or severe heart disease. Patients who are hypersensitive to alogliptin, metformin, or any component of this medication, or those who have experienced allergic reactions in the past, should not take it. Patients with moderate to severe impairment of kidney function or those with acute heart failure, acute myocardial infarction, or sepsis should not take this medication. If undergoing radiological tests using iodinated contrast agents, this medication should be temporarily discontinued before and after the test, and should be resumed only after confirming normal kidney function. This medication is not suitable for patients with type 1 diabetes, diabetic ketoacidosis, or diabetic pre-coma. Patients with severe infections or those undergoing surgery, or those with moderate to severe trauma may require insulin therapy instead of this medication. If surgical procedures are to be performed, discontinue this medication 48 hours prior to surgery, and resume only after confirming normal kidney function following the surgery. Patients with impaired liver function, those with pulmonary embolism or severe lung disease, those who consume alcohol excessively, or those with dehydration or severe gastrointestinal disorders should use caution when taking this medication. This medication lowers blood sugar levels; therefore, the risk of hypoglycemia may increase when used with other blood sugar-lowering agents, so blood sugar levels should be monitored closely. During treatment, side effects such as diarrhea, nausea, headache, back pain, and infections may occur. If symptoms are severe, consult a doctor. Women who are pregnant or may become pregnant should avoid taking this medication, and breastfeeding women should also avoid it. The elderly should undergo regular kidney function tests due to the potential for decreased kidney function and should be treated with the minimal effective dose. In case of overdose, medical monitoring and treatment are required, as lactic acidosis may occur due to metformin. This medication should be swallowed whole without chewing, breaking, or crushing, and the tablet shell may be excreted in feces, which is normal.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in the mucous membranes of the mouth/eyes, difficulty breathing or shortness of breath, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headache, lightning-like headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination issues.

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• diarrhea
• hypertension
• headache
• back pain
• urinary tract infection
• hypoglycemia
• nausea/vomiting
• bloating

This medication should be stored in an airtight container, preferably at a temperature between 1 and 30 degrees Celsius. This helps maintain the medication's effectiveness and prevents deterioration.

Appearance

Light yellow oval sustained release film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle