NPIANGDUO Tablet 12.5/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet once, twice a day. The dosage is determined based on each patient's current treatment regimen, effectiveness, and tolerability, without exceeding 25 mg of Empagliflozin and 2000 mg of Metformin. For patients who cannot achieve sufficient blood sugar control with Metformin alone or in combination with other medications such as insulin, the recommended dosage is 5 mg of Empagliflozin twice daily (total daily dose of 10 mg) and Metformin.

This medication is a diabetes treatment that helps control blood sugar. It can cause a rare but severe side effect known as lactic acidosis, so it should not be administered to patients with poor kidney function or severe infections, dehydration, or heart problems. Additionally, when used together with insulin or other blood sugar-lowering medications, hypoglycemia symptoms may occur, so caution is needed. This medication can be affected by kidney function, requiring regular kidney function tests before and during treatment. Particularly, in patients with severely reduced kidney function or those with acute illness or undergoing surgery, it should be avoided or temporarily discontinued. This medication may increase the risk of urinary tract infections and genital infections, so if any infection symptoms occur, consult healthcare professionals immediately. During treatment, gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain may occur, and hypoglycemia symptoms should also be monitored. It is safer for pregnant or breastfeeding women to avoid using this medication. Alcohol intake may increase the risk of side effects from this medication, thus it should be avoided. Elderly patients or those with poor nutritional status also require special caution when taking this medication. Patients taking this medication should have regular blood tests and kidney function tests, and any unusual symptoms should be discussed with a doctor immediately. Finally, patients taking this medication should store it out of reach of children and keep it in its original container.

Serious side effects

Severe lactic acidosis, ketoacidosis, perineal necrosis, hives, angioedema, severe edema, urosepsis, pyelonephritis, acute kidney injury, renal impairment, cerebrovascular accident, concussion, cerebral infarction, headache, myocardial infarction, angina pectoris, Prinzmetal angina, deep vein thrombosis, acute cholecystitis, autoimmune hepatitis, hepatitis, pneumonia, sepsis, fever, edema accompanied by elevated blood pressure, confusion, visual disturbances, paralysis, severe allergic reactions

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, so it must be stored in a tightly closed container. Additionally, avoid direct sunlight and store at room temperature between 1 to 30 degrees Celsius.

Appearance

A biconvex oval film-coated tablet with a dark brownish-purple color.

Package unit

10 tablets/box [(10 tablets/PTP × 1)], 60 tablets/box [(10 tablets/PTP × 6)], 30 tablets/bottle, 60 tablets/bottle