Empagliflozin/Metformin Hydrochloride Tablets 12.5/1000 mg

Adult dose

The recommended dose of this medication is 1 tablet once, twice a day. The daily maximum recommended doses for each ingredient, not exceeding empagliflozin 25 mg and metformin 2000 mg, should be considered based on the patient's current treatment regimen, efficacy, and tolerability. For patients not achieving sufficient blood glucose control with metformin alone or combination therapy with other medications such as insulin, the recommended dosage is to take empagliflozin 5 mg twice daily.

This medication is used for the treatment of diabetes and helps control blood glucose levels. However, it can cause a rare side effect called severe lactic acidosis, so it should not be used in patients with poor heart or kidney function. Additionally, there is a risk of hypoglycemia when used with insulin or other diabetes medications, so caution is needed. Patients with moderate to severe kidney function impairment, acute kidney problems, severe infections, heart failure, and other specific conditions should not take this medication. This medication should be temporarily discontinued before and after using iodine contrast agents for examinations, and can be resumed once kidney function has recovered. Pregnant or breastfeeding women should not take this medication, and it is also not recommended for children or adolescents under 18 years of age. Elderly patients should regularly monitor their kidney function, and dosage adjustments may be necessary. Patients taking this medication should carefully observe their hydration status in case of dehydration or gastrointestinal disturbances (nausea, vomiting, etc.), and may need to temporarily stop the medication if needed. This drug may increase the risk of urinary and genital infections, so if any symptoms of infection appear, consult a doctor immediately. Vitamin B12 levels may decrease, so regular checks may be necessary for those taking it long term. Alcohol may increase the risk of side effects of this medication, so avoid excessive drinking during treatment. Also, this medication may interact with other drugs, so inform your doctor or pharmacist if you are taking other medications. If symptoms of hypoglycemia (dizziness, cold sweat, severe fatigue, etc.) occur while taking this medication, check your blood glucose level immediately and take appropriate measures. Before surgery, discontinue this medication at least 48 hours prior, and can resume once kidney function returns to normal thereafter. Regular blood tests and kidney function monitoring are important during the use of this medication to check for any abnormalities.

Serious side effects

• Urticaria
• angioedema
• perineal necrosis
• ketoacidosis
• lactic acidosis
• severe allergic reactions
• severe skin adverse reactions
• urticaria
• erythema angioedema
• angioedema

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain storage temperatures between 1 to 30 degrees Celsius to safely preserve its efficacy.

Appearance

Biconvex oval film-coated tablets with a dark brown tint and purple color.

Package unit

10 tablets/box [10 tablets/PTP × 1], 60 tablets/box [10 tablets/PTP × 6], 30 tablets/bottle, 60 tablets/bottle